Kinetics of Ringer's Solution in Extracellular Dehydration and Hemorrhage.

Shock
Robert G HahnJ Zdolsek

Abstract

Ringer's solution might be used to treat volume depletion (extracellular dehydration) and hemorrhage, but there is no integrated view of how these fluid balance disorders influence the kinetics of the infused volume. Acute dehydration (mean 1.7 L) was induced by repeated doses of furosemide (5 mg) in 10 healthy male volunteers, and 0.5 L and 0.9 L of blood was withdrawn in random order on different occasions in another 10 male volunteers, just before administration of Ringer's acetate solution. Infusions performed in the normovolemic state served as controls. Measurements of blood hemoglobin and urinary excretion were used to create volume kinetic profiles that were analyzed using mixed-effects modeling software. Infusions over 15 to 30 min showed a marked distribution phase during which the plasma volume transiently increased by 50% to 75% of the administered volume. Dehydration and hemorrhage accelerated redistribution but retarded the elimination; the half-life of the infused fluid increased from 36 to 51 min (mean) from 1 L of dehydration and to 95 min from 1 L of hemorrhage. Extravascular accumulation decreased with the dehydration volume and increased with the hemorrhage volume.Simulations show that 60% as much Ringer is ...Continue Reading

References

Jan 9, 1975·The New England Journal of Medicine·R W Schrier, T Berl
Jan 23, 1999·Anesthesiology·D Drobin, R G Hahn
Aug 10, 2002·Anesthesiology·Dan Drobin, Robert G Hahn
Nov 23, 2005·Anesthesia and Analgesia·Joachim H ZdolsekRobert G Hahn
Jul 25, 2006·Anesthesia and Analgesia·Robert G HahnDonald S Prough
May 18, 2012·Critical Care : the Official Journal of the Critical Care Forum·Matthias JacobMarkus Rehm
Jul 6, 2012·Anesthesia and Analgesia·Joachim ZdolsekRobert G Hahn
Sep 6, 2012·Acta Anaesthesiologica Scandinavica·R G Hahn
Apr 3, 2014·Comprehensive Physiology·Samuel N Cheuvront, Robert W Kenefick
Jan 15, 2016·Acta Anaesthesiologica Scandinavica·R G HahnJ Zdolsek
Apr 30, 2017·Anesthesia and Analgesia·Robert G Hahn
Feb 2, 2019·World Journal of Nephrology·Muhammad AsimAdil Ghaffar

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Citations

Dec 22, 2019·Acta Anaesthesiologica Scandinavica·Robert G Hahn
Apr 15, 2020·Shock·David J Dries
Apr 10, 2020·Acta Anaesthesiologica Scandinavica·Robert G HahnJoachim Zdolsek
May 10, 2020·Acta Anaesthesiologica Scandinavica·Robert G HahnJoachim H Zdolsek
Nov 12, 2020·Acta Anaesthesiologica Scandinavica·Robert G Hahn
Dec 18, 2020·Frontiers in Veterinary Science·Xiu Ting YiewWilliam W Muir
Feb 2, 2021·Frontiers in Veterinary Science·Rosalind S Chow

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