Kinetics of serum androgen normalization and factors associated with testosterone reserve after limited androgen deprivation therapy for nonmetastatic prostate cancer.

The Journal of Urology
James L GulleyWilliam L Dahut

Abstract

Groups have investigated time to testosterone recovery in patients who have undergone androgen deprivation therapy, usually by measuring androgen every 3 months, with varying results. To our knowledge this represents the largest study using monthly testosterone and dihydroxytestosterone measurement to evaluate the kinetics of androgen recovery following limited androgen deprivation therapy. Monthly serum androgen levels were analyzed following 2, 6-month cycles of gonadotropin-releasing hormone agonist therapy as part of a randomized, placebo controlled study of the role of thalidomide in delaying time to prostate specific androgen progression. By the Kaplan-Meier method the median time to testosterone normalization in cycles 1 vs 2 was 15.4 vs 18.3 weeks with similar dihydroxytestosterone recovery times. Neither on-study prostate specific antigen, Gleason score nor thalidomide treatment had a significant impact on time to testosterone normalization. However, in cycle 1 men with low baseline dihydroxytestosterone and those who were more than 67 years old had significantly longer time to T normalization on Cox model analysis. Additionally, in cycle 2 patients with prior local radiation therapy had longer time to testosterone nor...Continue Reading

References

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Citations

Jan 29, 2013·Current Osteoporosis Reports·Stephen P TuckHarish K Datta
Sep 24, 2010·Endocrine-related Cancer·Nima SharifiWilliam L Dahut
Jun 26, 2009·Clinical Interventions in Aging·Rajni Sethi, Nicholas Sanfilippo
Jun 16, 2011·Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada·Howard Huaihan PaiEric Berthelet
Feb 15, 2013·The Journal of Sexual Medicine·Landon W TrostWayne J G Hellstrom
Sep 19, 2012·Seminars in Radiation Oncology·Ronald C ChenBryce B Reeve
Sep 22, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Claudio FiorinoGiuseppe Sanguineti
Oct 15, 2013·Clinical Physiology and Functional Imaging·Danielle GirardJack Cannon
Apr 3, 2012·Molecular and Cellular Endocrinology·Teuvo L J Tammela
Nov 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeanny B Aragon-Ching
May 12, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tomasz M BeerMark W Frohlich
May 9, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Almudena ZapateroFelipe A Calvo

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