Jul 1, 1977

Kinetics of sodium thiosulfate-35S fixation and effect of some sulfur compounds on iodine-131 fixation in ray thyroid gland

Annales d'endocrinologie
R PaulinJ P Lanza

Abstract

In order to invalidate or confirm the affirmation that non antithyroid sulphide molecules alter the measure of the thyroid fixation rate of iodine 131 we undertook on the rat: on one hand a kinetic study of thyroid fixation of sodium thiosulfate labelled with sulphur 35, which showed a very low captation not exceeding 0,01% of injected radioactivity; on the other hand the study of the effects of some sulphide molecules on thyroid fixation of iodine 131 in the rat: sodium thiosulfate, association of sodium thiosulfate + metalloidal sulphur + methionine, carbutamide and dimethylsulfoxyde in various kinds of dose administration and periods. None of the products used in our work conditions produced a significant decrease of the fixation rate of iodine 131. In three different experimental protocols (sulfur association and dimethylsulfoxide), we showed a significant light increase of the fixation rate.

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Mentioned in this Paper

Dimethyl Sulfoxide
Sulfides
Sulfur
Sample Fixation
Sulfur Compounds
Pedameth
Thyroid Diseases
Neoplasm of Uncertain or Unknown Behavior of Thyroid Gland
Thyroid (USP)
Iodine 131

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