PMID: 698213Sep 11, 1978Paper

Kinetics of the absorption of amino acids by the rat intestine in vivo

Biochimica Et Biophysica Acta
J A AntonioliJ W Robinson

Abstract

The kinetics of L-phenylalanine and L-lysine absorption by the rat small intestine in vivo have been studied by perfusing intestinal segments and monitoring simultaneously the uptake of the substrate into the intestinal tissue and its disappearance from the perfusate. The rate of phenylalanine disappearance is a linear function of the substrate concentration. Its uptake into the tissue is rapid and obeys saturation kinetics, but is not concentrative. Both tissue uptake and disappearance rate can be inhibited by leucine or methionine, but are not influenced by hydrophilic neutral or dibasic amino acids. Lysine disappearance from the perfusate and its uptake into the tissue both display saturation kinetics. Lysine transport is quantitatively smaller than that of phenylalanine. Both uptake and disappearance are inhibited by arginine and leucine, but are unaffected by other neutral amino acids or sugars. To analyse the kinetic results, integrated equations were developed to express the final concentration in the perfusate in terms of the original concentration. The disappearance rate was considered as a mixed process (saturable and non-saturable in parallel) in a one-compartment system, and the uptake by the tissue was treated as a...Continue Reading

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Citations

Apr 5, 1974·Naunyn-Schmiedeberg's Archives of Pharmacology·B Lichtenstein, D Winne
Jan 1, 1986·Comparative Biochemistry and Physiology. A, Comparative Physiology·F MurilloJ Bolufer
Jan 1, 1991·Comparative Biochemistry and Physiology. A, Comparative Physiology·T Roig, M P Vinardell
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Dec 21, 1981·Biochimica Et Biophysica Acta·J J Hajjar, H P Schedl
Jul 1, 1994·Biopharmaceutics & Drug Disposition·A NácherM Merino
Jan 1, 1982·Die Nahrung·M Friedrich

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