Kinetics of the "black hole" phenomenon in ultrasound backscattering measurements with red blood cell aggregation

Ultrasound in Medicine & Biology
Z QinGuy Cloutier

Abstract

The observation of a hypoechoic zone around the center of large tubes (the "black hole" phenomenon) in ultrasound backscattering measurements with red blood cell (RBC) aggregation was reported for the first time in 1989. Since then, a very limited number of studies tried to explain its complex mechanisms. In this study, blood models characterized by different RBC aggregation levels were prepared by diluting horse blood plasma with a saline solution in different proportions. A laser reflectometry technique was used to characterize the RBC aggregation kinetics and cohesion forces between RBCs for each blood sample. The blood was circulated in a 12.7 mm diameter vertical tube. For each experimental flow condition tested, 25 or 15 power Doppler ultrasound measurements were performed across the tube with a 10-MHz system and insonation angles varying between 40 degrees to 70 degrees. For flow rates varying between 100 and 1250 mL/min, the "black hole" was observed in most measurements performed with different aggregating RBC models. The "black hole" was more pronounced for RBCs with a high kinetics of aggregation and measurements with increasing Doppler angles. Previous studies suggested that this phenomenon is due to tube entrance e...Continue Reading

References

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Citations

Feb 14, 2004·Ultrasound in Medicine & Biology·Dong-Guk PaengK Kirk Shung
May 17, 2003·Ultrasound in Medicine & Biology·Fermín A LupottiAntonius F W van der Steen
Jul 7, 2007·The Journal of the Acoustical Society of America·François T H Yu, Guy Cloutier
Mar 23, 2011·Ultrasound in Medicine & Biology·Ying LiDong-Guk Paeng
Jun 20, 2015·Scientific Reports·Eunseop YeomSang Joon Lee
Jul 4, 2003·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Dong-Guk Paeng, K Kirk Shung
May 2, 2009·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Dong-Guk PaengK Kirk Shung
Jun 29, 2004·Ultrasound in Medicine & Biology·Dong-Guk PaengK Kirk Shung
May 3, 2014·Ultrasound in Medicine & Biology·Kweon-Ho Nam, Dong-Guk Paeng
Jun 30, 2015·Ultrasound in Medicine & Biology·Julian Garcia-DuitamaGuy Cloutier
Sep 24, 2002·The Journal of the Acoustical Society of America·Constantin C Coussios
Oct 16, 2018·Clinical Hemorheology and Microcirculation·Fatma UnverMelek Bor-Kucukatay

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