Kinetics of the glomerular ultrafiltration in the rat kidney. A theoretical study.

Acta Physiologica Scandinavica
O KällskogM Wolgast

Abstract

The glomerular filtration process was evaluated theoretically from micropuncture data obtained from Sprague-Dawley rats. The hydrostatic pressures in the glomerular capillaries and Bowman's space minus the oncotic pressure in systemic plasma gave the net driving force at the proximal end of the glomerular capillary. From the single nephron filtration fraction the mean net driving force over the glomerular membrane was calculated to be 20 mm Hg during normotension, decreasing to 12 mm Hg during a perfusion pressure of 80 mm Hg. The hydraulic permeability for one glomerulus was 0.7-0.8 nl/min-100 g b.wt. mmHg. The pressures at the distal end of the glomerular capillaries were 13 and 6 mm Hg under the above two conditions, indicating non-equilibrium of the filtration process at the end of the glomerular capillary. It was shown that the glomerular filtration rate is mainly influenced by the driving pressures. During hypotension an increased plasma flow dependency was evident. Brenner et al. found a filtration equilibrium and a plasma flow dependent glomerular filtration rate in a mutant Wistar rat strain. The discrepancy between their results and ours is due to the low glomerular plasma flow and hydrostatic pressures in the Wistar ...Continue Reading

References

Nov 1, 1975·Acta Physiologica Scandinavica·O KällskogM Wolgast
Sep 1, 1972·Kidney International·P P LambertP Ficheroulle
Jun 1, 1973·The Journal of Clinical Investigation·W M DeenB M Brenner
May 18, 1973·Pflügers Archiv : European journal of physiology·M WolgastP Wunderlich
Oct 1, 1973·The Journal of General Physiology·A VernioryP P Lambert
Mar 1, 1974·The American Journal of Physiology·J P GasseeP P Lambert
Aug 1, 1971·The Journal of Clinical Investigation·B M BrennerT M Daugharty
Jan 1, 1971·Pflügers Archiv : European journal of physiology·P WunderlichM Wolgast
Jan 1, 1966·Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere·K H GertzH D Pagel
May 1, 1968·The American Journal of Physiology·J E Lewy, E E Windhager
May 1, 1969·Acta Physiologica Scandinavica·F KiilE Löyning
Jan 1, 1952·Scandinavian Journal of Clinical and Laboratory Investigation·G WALLENIUS

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Citations

Aug 1, 1981·Pflügers Archiv : European journal of physiology·B E Persson
Nov 1, 1975·Acta Physiologica Scandinavica·O KällskogM Wolgast
Dec 1, 1977·Acta Physiologica Scandinavica·K AuklandG Naess
Aug 1, 1981·Acta Physiologica Scandinavica·P K JensenK Steven
Feb 1, 1995·Acta Physiologica Scandinavica·M Broman, O Källskog
Jun 4, 2010·Acta Physiologica·P PerssonF Palm
Aug 1, 1981·Kidney International·M SteinhausenF D Dallenbach
Aug 1, 1982·Kidney International·D E Oken
Jul 1, 1978·Kidney International·B J NorlénM Wolgast
Mar 31, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Liselotte PihlFredrik Palm

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