Kinetics of the TEA and 4-AP sensitive K+ current in the slowly adapting lobster stretch receptor neurone

Acta Physiologica Scandinavica
S Gestrelius, W Grampp


The kinetics of the TEA and 4-AP sensitive K+ current (IK) in the slowly adapting lobster stretch receptor neurone were investigated in sub- and near-threshold voltage regions using electrophysiological and pharmacological techniques. In dynamic conditions IK was found to display both fast and slow reactions. These were attributed to a Hodgkin-Huxley type of K activation, and a slow type of K inactivation, respectively. The slow K inactivation could be shown to be unrelated to K+ flux dependent changes in intra- and pericellular K+ concentrations. Its stationary voltage dependence was however shifted in a depolarizing direction by increasing, and in hyperpolarizing direction by decreasing the extracellular Ca++ concentration. In view of these findings, and of its kinetic properties, the slow K inactivation was classified as a genuine channel gating process. The process of K activation was too fast for a dynamic analysis with the recording technique available. An estimate of its stationary voltage dependence could however be obtained in a voltage range from about -100 to about -40 mV. The experimental observations were utilized in the formulation of a mathematical model describing the kinetic behaviour of IK in the present prepa...Continue Reading


Jan 1, 1979·The Journal of Physiology·L Cleemann, M Morad
Jul 1, 1978·Journal of Neurophysiology·C NicholsonR Steinberg
Aug 1, 1975·Biophysical Journal·G EhrensteinR J Lipicky
Jun 1, 1972·Acta Physiologica Scandinavica·T Brismar, B Frankenhaeuser
Jan 1, 1971·Pflügers Archiv : European journal of physiology·J R Schwarz, W Vogel
Feb 1, 1971·The Journal of Physiology·J A Connor, C F Stevens
Sep 1, 1966·Biophysical Journal·G Ehrenstein, D L Gilbert
Jul 1, 1983·Acta Physiologica Scandinavica·A EdmanW Grampp
Jan 1, 1981·The Journal of Physiology·S GestreliusL Sjölin
Sep 1, 1980·The Journal of Physiology·H BrownS Noble
Feb 28, 1956·The Journal of Physiology·B FRANKENHAEUSER, A L HODGKIN
Oct 1, 1959·The Journal of Physiology·B FRANKENHAEUSER, B WALTMAN
Jul 1, 1962·The Journal of General Physiology·F J JULIAND E GOLDMAN
Jul 1, 1962·The Journal of General Physiology·F J JULIAND E GOLDMAN
Dec 1, 1969·The Journal of Membrane Biology·R W Tsien, D Noble

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Jan 13, 2000·Acta Physiologica Scandinavica·S TheanderW Grampp
Jun 1, 1983·Acta Physiologica Scandinavica·S GestreliusL Sjölin
Jul 1, 1983·Acta Physiologica Scandinavica·A EdmanW Grampp
Sep 25, 2002·Journal of Theoretical Biology·C FåhraeusW Grampp

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