Kinetics of Torque Teno Virus-DNA Plasma Load Predict Rejection in Lung Transplant Recipients

Transplantation
Björn C FryeJoachim Müller-Quernheim

Abstract

Lung transplantation is the only therapeutic option in end-stage lung diseases; however, survival after transplantation is limited by acute and chronic rejection or infectious events being results of inappropriate immunosuppression. Torque Teno Viruses (TTVs) are ubiquitous DNA viruses in humans but not found to be causative for any disease. However, some reports suggest that TTV-DNA levels reflect the grade of immunosuppression with higher levels being found in more immunosuppressed individuals. We investigated the TTV-DNA levels in 34 lung transplant recipients within their first year after transplantation by quantitative real-time polymerase chain reaction. Clinical data were extracted from charts. In accordance with previous results TTV-DNA levels increase after lung transplantation reaching a steady state after 3 months. The TTV-DNA levels were not correlated with immunosuppressive trough levels and a selective increase was not observed with other DNA viruses. In steady state TTV-DNA levels were significantly higher in patients with infectious complications compared to the group of patients without. Additionally, TTV-DNA levels decreased significantly before biopsy-proven rejection. Sensitivity of a 10-fold decrease in TTV...Continue Reading

References

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Citations

Feb 23, 2020·Expert Review of Anti-infective Therapy·Mario Fernández-RuizJosé María Aguado
Feb 9, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Konstantin DobererGregor Bond
Jun 12, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Phoebe UhlKrisztina Rusai
May 1, 2020·World Journal of Gastroenterology : WJG·Vasiliy I ReshetnyakTatiana I Karlovich
Sep 29, 2020·Transplantation Proceedings·Björn Christian FryeJoachim Müller-Quernheim
Mar 29, 2020·American Journal of Ophthalmology·Cecilia S LeeUNKNOWN Endophthalmitis Study Group
Jun 15, 2021·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·John E McGinnissRonald G Collman
Jan 24, 2020·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·D FocosiF Maggi

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