Kinetics of urinary trypsin inhibitor in patients undergoing partial hepatectomy

Scandinavian Journal of Gastroenterology
T NoieM Makuuchi

Abstract

The kinetics and role of urinary trypsin inhibitor (UTI) in liver surgery are unclear. We investigated the effects of preoperative liver function and the extent of liver resection on postoperative UTI synthesis in the liver after partial hepatectomy. Sixty-one consecutive patients who underwent liver resection were the subjects of the study. Plasma and urine UTI, plasma C reactive protein (CRP) and plasma and urine creatinine were measured perioperatively. Although the average plasma UTI level did not change significantly, the average urine UTI level per day showed a change similar to that of the average plasma CRP level, reaching a maximum of approximately eight times the preoperative level on the second postoperative day (86,610 +/- 53,109 U/day). The maximum postoperative increase in urine UTI excretion per day (delta-uUTImax) correlated significantly with the maximum increase in CRP and the increase in creatinine clearance. Multiple regression analysis revealed that delta-uUTImax was significantly and positively correlated with the indocyanine green plasma disappearance rate and operation duration, and negatively correlated with the resection rate. The postoperative urine UTI level may reflect preoperative liver function an...Continue Reading

References

Nov 1, 1989·Biological Chemistry Hoppe-Seyler·B M Jönsson-BerlingM Rosengren
Feb 1, 1994·Immunology Today·H Baumann, J Gauldie
Mar 1, 1997·The Journal of Pathology·H Moshage

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Citations

Jan 18, 2013·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Liliane MpabanziSteven W M Olde Damink
Aug 10, 2004·World Journal of Gastroenterology : WJG·Chi-Hua FangWei Zhang
Sep 5, 2002·Clinical Chemistry and Laboratory Medicine : CCLM·Charlotte MizonJacques Mizon

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