Kinetochore assembly and disassembly during mitotic entry and exit

Current Opinion in Cell Biology
Masatoshi Hara, Tatsuo Fukagawa

Abstract

Faithful chromosome segregation during mitosis in eukaryotes requires a large protein complex, kinetochore, formed on the centromere of each chromosome, to attach to spindle microtubules. Among the kinetochore proteins, Constitutive Centromere-Associated Network (CCAN) and KMN-network proteins form the base of the vertebrate kinetochore architecture. The CCAN proteins constitutively localize to the centromere throughout the cell cycle, whereas KMN-network proteins are recruited to the CCAN only during mitosis. Recent studies in cellular and structural biology, as well as biochemical reconstitutions, have revealed that mitotic phosphorylation of kinetochore proteins has critical roles in kinetochore organization. Here, we discuss the molecular processes of kinetochore assembly during mitotic entry and its disassembly during mitotic exit.

Citations

May 11, 2019·Cell Cycle·Masatoshi Hara, Tatsuo Fukagawa
Sep 19, 2019·The Journal of Cell Biology·Mary Kate BonnerAlexander E Kelly
Nov 5, 2019·The Journal of Cell Biology·Reito WatanabeTatsuo Fukagawa
Jun 17, 2020·Cell Cycle·João BarbosaClaudio Sunkel
Jun 15, 2020·Cancer Science·Megumi SaitoYuichi Wakabayashi
Aug 18, 2018·Journal of Cell Science·Julie K Monda, Iain M Cheeseman
Nov 14, 2018·Nature Cell Biology·Masatoshi HaraTatsuo Fukagawa
Nov 14, 2018·Nature Cell Biology·Yang Yang, Hongtao Yu
Dec 31, 2020·ELife·Jacob A HermanSue Biggins
Nov 13, 2019·Structure·Yoshimasa TakizawaHitoshi Kurumizaka
Feb 26, 2020·Current Biology : CB·Alexandra P Navarro, Iain M Cheeseman
Mar 19, 2021·Bio-protocol·Reito WatanabeTatsuo Fukagawa
Apr 17, 2021·Cellular and Molecular Life Sciences : CMLS·Cenna Doornbos, Ronald Roepman
Apr 11, 2021·Seminars in Cell & Developmental Biology·James R PaulsonWilliam C Earnshaw
Jun 4, 2021·The Journal of Cell Biology·Gabriele MarcianòBungo Akiyoshi
Sep 12, 2021·Nature Reviews. Molecular Cell Biology·Helen K MatthewsRobertus A M de Bruin
Jan 9, 2022·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Reito WatanabeTatsuo Fukagawa
Jan 5, 2021··Reito WatanabeMasatoshi HHara

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