Jan 10, 2008

Kinetochore-microtubule interactions: the means to the end

Current Opinion in Cell Biology
Tomoyuki U Tanaka, Arshad Desai

Abstract

Kinetochores are proteinaceous complexes containing dozens of components; they are assembled at centromeric DNA regions and provide the major microtubule attachment site on chromosomes during cell division. Recent studies have defined the kinetochore components comprising the direct interface with spindle microtubules, primarily through structural and functional analysis of the Ndc80 and Dam1 complexes. These studies have facilitated our understanding of how kinetochores remain attached to the end of dynamic microtubules and how proper orientation of a kinetochore-microtubule attachment is promoted on the mitotic spindle. In this article, we review these recent studies and summarize their key findings.

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Citations

Mentioned in this Paper

Vertebrates
Electron Microscope Tomography
Establishment and Maintenance of Localization
SPC24 gene
Spindle
Dynein Activity
BCAS2 gene
Cell Motility
BCAS2 wt Allele
Mitotic Spindle Apparatus

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