King of hearts: a splicing factor rules cardiac proteins.

Nature Medicine
Wolfgang A Linke, Sandra Bücker

Abstract

Alternative splicing ensures the expression of functionally diverse proteins from individual genes; however, aberrant mRNA splicing is associated with various conditions, including heart disease. A recent study provides new mechanistic insights into heart failure by showing that a human cardiomyopathy-linked mutation in a cardiac splice factor affects post-transcriptional regulation, causing the expression of anomalous isoforms of a whole network of cardiac proteins (pages 766-773).

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Citations

Mar 26, 2014·Pflügers Archiv : European journal of physiology·James D GladdenMargaret M Redfield
Jul 28, 2013·FEBS Letters·Agnese FilippelloMaria Grazia Romanelli
Jan 28, 2016·Wiley Interdisciplinary Reviews. RNA·Miguel B CoelhoChristopher W J Smith
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Nov 15, 2020·Nature Medicine·Jay W SchneiderUNKNOWN Wanek Program Preclinical Pipeline

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Journal of the American College of Cardiology
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Journal of the American College of Cardiology
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