Kinin B1 and B2 receptor deficiency protects against obesity induced by a high-fat diet and improves glucose tolerance in mice

Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy
Rafael L MoraisJoao Bosco Pesquero

Abstract

The kallikrein-kinin system is well known for its role in pain and inflammation, and has been shown recently by our group to have a role also in the regulation of energy expenditure. We have demonstrated that B1 receptor knockout (B1KO) mice are resistant to obesity induced by a high-fat diet (HFD) and that B1 receptor expression in adipocytes regulates glucose tolerance and predisposition to obesity. However, it is also known that in the absence of B1 receptor, the B2 receptor is overexpressed and can take over the function of its B1 counterpart, rendering uncertain the role of each kinin receptor in these metabolic effects. Therefore, we investigated the impact of ablation of each kinin receptor on energy metabolism using double kinin receptor knockout (B1B2KO) mice. Our data show that B1B2KO mice were resistant to HFD-induced obesity, with lower food intake and feed efficiency when compared with wild-type mice. They also had lower blood insulin and leptin levels and higher glucose tolerance after treatment with an HFD. Gene expression for tumor necrosis factor-alpha and C-reactive protein, which are important genes for insulin resistance, was reduced in white adipose tissue, skeletal muscle, and the liver in B1B2KO mice afte...Continue Reading

Citations

May 14, 2016·Canadian Journal of Physiology and Pharmacology·Sébastien TalbotRéjean Couture
Jul 7, 2017·American Journal of Physiology. Endocrinology and Metabolism·María E FrigoletI George Fantus
Oct 22, 2019·Frontiers in Molecular Neuroscience·Bingyuan JiYili Wu
May 16, 2017·Frontiers in Physiology·Thássio R R MesquitaSandra Lauton-Santos

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