Kinin-mediated antihypertensive effect of captopril in deoxycorticosterone acetate-salt hypertension

Hypertension
K ChenB G Zimmerman

Abstract

On the basis of evidence suggesting the activation of the kallikrein-kinin system in steroid-induced hypertension, we considered the possibility that the angiotensin-converting enzyme inhibitor captopril would lower the arterial blood pressure in deoxycorticosterone acetate (DOCA)-salt hypertensive rats through kininase II inhibition. In conscious DOCA-salt hypertensive rats with intact kidneys (n = 6) or uninephrectomized rats (n = 5), the short-term administration of captopril (8 mg/kg IV) decreased mean blood pressure from 141 +/- 3 to 118 +/- 3 mm Hg (P < .05) and from 176 +/- 12 to 158 +/- 15 mm Hg (P < .05), respectively. The maximal effect of captopril was manifested between 40 and 50 minutes after its administration, and blood pressure remained depressed for at least 2 hours. The bradykinin B2 receptor antagonist Hoe 140 (500 micrograms/kg IV) abolished the antihypertensive effect of captopril in the DOCA-salt hypertensive rats, indicating kinin involvement. Losartan, an angiotensin type 1 receptor antagonist, had no effect on blood pressure in another group of DOCA-salt hypertensive rats (n = 9) and did not significantly change the response to captopril. No effect of the angiotensin-converting enzyme inhibitor was seen...Continue Reading

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Citations

Sep 7, 2000·General Pharmacology·V W NunesR Scivoletto
Apr 25, 2000·Clinical and Experimental Pharmacology & Physiology·L BrownC Sernia
Apr 5, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kazuaki YokotaHirofumi Makino
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Oct 29, 2000·Journal of the American Society of Nephrology : JASN·Maria C DE GraciaFelix Vargas

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