Kinin-mediated inflammation in neurodegenerative disorders

Neurochemistry International
Ibeth Guevara-Lora

Abstract

The mediatory role of kinins in both acute and chronic inflammation within nervous tissues has been widely described. Bradykinin, the major representative of these bioactive peptides, is one of a few mediators of inflammation that directly stimulates afferent nerves due to the broad expression of specific kinin receptors in cell types in these tissues. Moreover, kinins may be delivered to a site of injury not only after their production at the endothelium surface but also following their local production through the enzymatic degradation of kininogens at the surface of nerve cells. A strong correlation between inflammatory processes and neurodegeneration has been established. The activation of nerve cells, particularly microglia, in response to injury, trauma or infection initiates a number of reactions in the neuronal neighborhood that can lead to cell death after the prolonged action of inflammatory substances. In recent years, there has been a growing interest in the effects of kinins on neuronal destruction. In these studies, the overexpression of proteins involved in kinin generation or of kinin receptors has been observed in several neurologic disorders including neurodegenerative diseases such Alzheimer's disease and mul...Continue Reading

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Citations

Jul 16, 2013·Progress in Neurobiology·Marijke De BockLuc Leybaert
Aug 21, 2013·Expert Opinion on Therapeutic Targets·Nelly Blaes, Jean-Pierre Girolami
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Oct 11, 2016·Mediators of Inflammation·Anna Niewiarowska-SendoIbeth Guevara-Lora
Feb 19, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yacine TabetÉric Rousseau

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