PMID: 8446605Mar 1, 1993Paper

Kinship bioassay on hypervariable loci in blacks and Caucasians

Proceedings of the National Academy of Sciences of the United States of America
N E MortonI Balazs

Abstract

Four hypervariable loci were examined in DNA samples of American Blacks and Caucasians. Genetic diversity, measured by mean kinship within race, is 0.004 for a sliding window equal to twice the radius of coalescence of the autoradiographic bands. Kinship increases with the width of a window or bin, but it is an order of magnitude less than for blood groups and isozymes. This must reflect the greater mutability of hypervariable loci and absence of divergent selection. Low kinship implies that matching probabilities do not depend critically on race. Complete matching between pairs of loci shows deviations from independence, presumably because of inadvertent inclusion of replicated samples or related individuals. Multilocus matching probabilities were corrected for this (possibly spurious) dependence; the correction is negligible. When the complexities of coalescence, kinship, and dependent matching are allowed for, the probability calculations used in forensic identification are reliable. Recent counterarguments without theoretical basis or empirical support are discussed.

References

Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·B S Weir
Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·N E Morton
Dec 20, 1991·Science·R Chakraborty, K K Kidd
Dec 20, 1991·Science·R C Lewontin, D L Hartl
Nov 21, 1991·Nature·A J JeffreysD G Monckton
Jul 1, 1966·Vox Sanguinis·M P Mi, N E Morton

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Citations

Sep 1, 1995·Electrophoresis·J F Brookfield
Sep 1, 1995·Electrophoresis·N E Morton, A E Collins
Jan 1, 1996·International Journal of Legal Medicine·D J BaldingR A Nichols
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·A Collins, N E Morton
Dec 5, 1995·Proceedings of the National Academy of Sciences of the United States of America·D J Balding, P Donnelly
Jan 1, 1995·Genetica·N E Morton
Jan 1, 1995·Genetica·P Gill, I Evett
May 5, 2000·Science & Justice : Journal of the Forensic Science Society·J W LeeJ J Hwang
Jan 1, 1993·Statistical Methods in Medical Research·B Devlin
Oct 27, 1994·Nature·E S Lander, B Budowle
Apr 1, 1999·Evolution; International Journal of Organic Evolution·Philip W Hedrick
May 21, 1993·Science·B DevlinK Roeder
May 21, 1993·Science·R Chakraborty

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