KIR channels function as electrical amplifiers in rat vascular smooth muscle.

The Journal of Physiology
Pamela D SmithDonald G Welsh

Abstract

Strong inward rectifying K(+) (K(IR)) channels have been observed in vascular smooth muscle and can display negative slope conductance. In principle, this biophysical characteristic could enable K(IR) channels to 'amplify' responses initiated by other K(+) conductances. To test this, we have characterized the diversity of smooth muscle K(IR) properties in resistance arteries, confirmed the presence of negative slope conductance and then determined whether K(IR) inhibition alters the responsiveness of middle cerebral, coronary septal and third-order mesenteric arteries to K(+) channel activators. Our initial characterization revealed that smooth muscle K(IR) channels were highly expressed in cerebral and coronary, but not mesenteric arteries. These channels comprised K(IR)2.1 and 2.2 subunits and electrophysiological recordings demonstrated that they display negative slope conductance. Computational modelling predicted that a K(IR)-like current could amplify the hyperpolarization and dilatation initiated by a vascular K(+) conductance. This prediction was consistent with experimental observations which showed that 30 mum Ba(2+) attenuated the ability of K(+) channel activators to dilate cerebral and coronary arteries. This atten...Continue Reading

References

Mar 1, 1991·The American Journal of Physiology·A Koller, G Kaley
Jul 1, 1990·The American Journal of Physiology·M T NelsonN B Standen
May 1, 1990·Circulation Research·J L Garcia-Roldan, J A Bevan
Nov 1, 1993·The American Journal of Physiology·J M QuayleM T Nelson
Apr 1, 1995·The American Journal of Physiology·M T Nelson, J M Quayle
Nov 14, 1997·Physiological Reviews·J M QuayleN B Standen
Jan 28, 1998·Stroke; a Journal of Cerebral Circulation·D R HarderR J Roman
Mar 6, 1999·The Journal of Physiology·K K BradleyB Horowitz
Apr 12, 2000·Acta Physiologica Scandinavica·S S Segal
May 18, 2001·American Journal of Physiology. Heart and Circulatory Physiology·D G Welsh, J E Brayden
Oct 3, 2001·Physiological Reviews·B Nilius, G Droogmans
Feb 25, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Tom KarkanisStephen M Sims
Jun 14, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Sean P MarrelliMichael S Hunte
Nov 1, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Kevin D LuykenaarDonald G Welsh
Nov 18, 2003·Nature Reviews. Neuroscience·Delphine BichetLily Yeh Jan
Mar 18, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Gillian Edwards, Arthur H Weston
Sep 4, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Ossama A HatoumDavid D Gutterman
Jan 19, 2005·British Journal of Pharmacology·Pascale GluaisMichel Félétou
Jun 17, 2005·American Journal of Physiology. Cell Physiology·Yun FangIrena Levitan
Jan 31, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Elke M SokoyaMarianne Tare
Mar 25, 2006·Stroke; a Journal of Cerebral Circulation·Alister J McNeishChristopher J Garland
Mar 28, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Robert M BryanSean P Marrelli
Jul 19, 2006·Pflügers Archiv : European journal of physiology·Didier X P Brochet, Philip D Langton
May 28, 1902·The Journal of Physiology·W M Bayliss
Oct 3, 2006·Nature Neuroscience·Jessica A FilosaMark T Nelson
Oct 24, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Bin-Nan WuDonald G Welsh
Oct 31, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Sean P MarrelliRobert M Bryan

❮ Previous
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Citations

Jun 24, 2011·Cardiovascular Research·Lisa ChiltonRodger Loutzenhiser
Nov 21, 2008·Clinical and Experimental Pharmacology & Physiology·Shaun L SandowFrances Plane
Sep 10, 2010·American Journal of Physiology. Cell Physiology·Albert L GonzalesScott Earley
Jan 24, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Francesco VetriDale A Pelligrino
Jan 8, 2011·Journal of Biomedical Science·I-Shan ChenBin-Nan Wu
Feb 22, 2014·Pflügers Archiv : European journal of physiology·Eun Yeong SeoSung Joon Kim
Feb 11, 2015·TheScientificWorldJournal·Martapolyana T M SilvaLuciano A A Ribeiro
Dec 20, 2012·Stroke Research and Treatment·Marcel A KampDaniel Hänggi
Jul 29, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Maria SanchoDonald G Welsh
Apr 4, 2017·Acta Physiologica·M SalomonssonC M Sorensen
Apr 21, 2010·Experimental Biology and Medicine·Gregory M Dick, Johnathan D Tune
Jul 20, 2017·Physiological Reports·Eun Yeong SuhSung Joon Kim
Apr 23, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Sebastien HayozWilliam F Jackson
Aug 11, 2017·Channels·Christopher M Hearon, Frank A Dinenno
Sep 11, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Marilyn J CipollaSiu-Lung Chan
Mar 20, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Pilar CidadJosé R López-López
Dec 7, 2018·The Journal of Physiology·Christopher M HearonFrank A Dinenno
Apr 9, 2010·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Cam Ha T Tran, Donald G Welsh
Jan 27, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Maria SanchoDonald G Welsh
May 3, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Maria SanchoDonald G Welsh
Feb 9, 2012·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Caryl E Hill
Feb 22, 2012·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Sridevi NagarajaNikolaos M Tsoukias
Sep 13, 2013·American Journal of Physiology. Cell Physiology·Michelle N Sullivan, Scott Earley
Dec 15, 2015·Journal of Cardiovascular Pharmacology·Michel Félétou
Dec 16, 2011·American Journal of Physiology. Renal Physiology·Charlotte Mehlin SorensenMax Salomonsson
Feb 1, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Maria SanchoDonald G Welsh
Apr 25, 2020·The Journal of Physiology·Janée D TerwoordFrank A Dinenno
Jul 24, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Ibra S FancherIrena Levitan
Aug 16, 2017·Biophysics Reviews·Cesar C CeballosRicardo M Leão
Sep 29, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Bjørn Olav Hald, Donald G Welsh
Feb 3, 2015·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Thomas A Longden, Mark T Nelson
Sep 23, 2016·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·William F Jackson
Nov 25, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Md A HakimErik J Behringer
Jan 8, 2020·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Sung Eun KimSung Joon Kim

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