KIR2DS5 in the presence of HLA-C C2 protects against endometriosis

Immunogenetics
I NowakP Kuśnierczyk

Abstract

Endometriosis is defined as the presence of functional endometrial tissue outside the uterine cavity. Several hypotheses have attempted to explain the etiology and pathogenesis of endometriosis. Recently, it has been suggested that a defect of the natural killer (NK) activity in the recognition and lysis of endometrial cells is one of the crucial points in the development of this disease. Natural killer cells can express killer immunoglobulin-like receptors (KIR), which recognize class I human leukocyte antigens on target cells. We asked whether polymorphisms in KIR, HLA-C, and HLA-B genes are risk factors for endometriosis. We tested 153 women with endometriosis diagnosed on the basis of laparoscopic and histological examination, and 213 control healthy women, who gave birth to at least one child. The frequency of KIR genes in patients was similar to that in controls except for KIR2DS5, which exerted a protective effect only in HLA-C C2-positive individuals. Moreover, KIR2DS5-positive women with endometriosis had 13 times lower chance that the disease would occupy the peritoneum than KIR2DS5- and KIR2DS4del-negative ones (OR = 0.077, P = 0.0061). Similarly, KIR2DS4del-positive endometriotic persons had 11 times lower chance fo...Continue Reading

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Jan 20, 2016·American Journal of Reproductive Immunology : AJRI·Kirstin L Parkin, Asgerally T Fazleabas
Jun 24, 2015·Human Genetics·Danillo G Augusto, Maria Luiza Petzl-Erler
Sep 22, 2019·Journal of Clinical Medicine·Aneta ŚcieżyńskaJacek Malejczyk
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Jul 12, 2017·Immunogenetics·Hugo G Hilton, Peter Parham
Dec 14, 2017·Molecular Genetics and Genomics : MGG·Aleksandra BylińskaIzabela Nowak
Jul 15, 2020·Reproductive Sciences·Maria Lucia Carnevale MarinJorge Kalil
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Nov 7, 2020·International Journal of Molecular Sciences·Beata SmolarzHanna Romanowicz

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Methods Mentioned

BETA
genotyping

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