KIR3DL1/HLA-B Subtypes Govern Acute Myelogenous Leukemia Relapse After Hematopoietic Cell Transplantation

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Jeanette E BoudreauKatharine C Hsu

Abstract

Purpose Disease relapse remains a major challenge to successful outcomes in patients who undergo allogeneic hematopoietic cell transplantation (HCT). Donor natural killer (NK) cell alloreactivity in HCT can control leukemic relapse, but capturing alloreactivity in HLA-matched HCT has been elusive. HLA expression on leukemia cells-upregulated in the post-HCT environment-signals for NK cell inhibition via inhibitory killer immunoglobulin-like (KIR) receptors and interrupts their antitumor activity. We hypothesized that varied strengths of inhibition among subtypes of the ubiquitous KIR3DL1 and its cognate ligand, HLA-B, would titrate NK reactivity against acute myelogenous leukemia (AML). Patients and Methods By using an algorithm that was based on polymorphism-driven expression levels and specificities, we predicted and tested inhibitory and cytotoxic NK potential on the basis of KIR3DL1/HLA-B subtype combinations in vitro and evaluated their impact in 1,328 patients with AML who underwent HCT from 9/10 or 10/10 HLA-matched unrelated donors. Results Segregated by KIR3DL1 subtype, NK cells demonstrated reproducible patterns of strong, weak, or noninhibition by target cells with defined HLA-B subtypes, which translated into discre...Continue Reading

References

Feb 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C M GardinerP Parham
Oct 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katharine C HsuBo Dupont
Dec 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marcelo J PandoPeter Parham
Jun 29, 2004·Human Immunology·Iris A HalfpennyFionnuala Williams
Feb 19, 2005·Nature Reviews. Immunology·Peter Parham
Oct 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·William Henry CarrPeter Parham
Jul 26, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Katharine C HsuUNKNOWN International Histocompatibility Working Group
Aug 12, 2006·Immunity·Nicolas AnfossiEric Vivier
Dec 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Geraldine M O'ConnorClair M Gardiner
Apr 7, 2007·AIDS Research and Human Retroviruses·Geraldine M A GillespieMary Carrington
May 15, 2007·Nature Genetics·Maureen P MartinMary Carrington
Sep 18, 2007·Human Immunology·Tatiana V LebedevaNeng Yu
Jul 14, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michel DuvalDaniel Weisdorf
Dec 1, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sabrina B TanerFrances M Brodsky
Jun 22, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peter ParhamLisbeth A Guethlein
Aug 7, 2012·The Journal of Clinical Investigation·Nidale TarekKatharine C Hsu
Sep 17, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Alan S WayneMichael R Bishop
Sep 21, 2013·Nature Immunology·Thomas F GajewskiYang-Xin Fu
Feb 25, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Geraldine M O'ConnorDaniel W McVicar
Apr 22, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sarah CooleyJeffrey S Miller
Mar 11, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jeanette E BoudreauKatharine C Hsu
Apr 6, 2016·The Journal of Experimental Medicine·Philippa M SaundersJulian P Vivian
Apr 14, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christopher J ForlenzaKatharine C Hsu

❮ Previous
Next ❯

Citations

Sep 18, 2018·Current Opinion in Oncology·Sara Lozano CerradaEduardo Olavarria
Jan 11, 2019·Cancers·Alexander David Barrow, Marco Colonna
Feb 1, 2018·International Journal of Hematology·Rohtesh S MehtaKatayoun Rezvani
Feb 9, 2020·International Journal of Immunogenetics·Alexander H SchmidtJohannes Schetelig
Mar 14, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeong A Park, Nai-Kong V Cheung
Nov 22, 2017·Immunology·Maneesh K MisraJill A Hollenbach
Mar 3, 2020·Frontiers in Immunology·Susanne H C BaumeisterRizwan Romee
Oct 7, 2018·Scientific Reports·Jean-Benoît Le LuduecKatharine C Hsu
Aug 29, 2019·Frontiers in Immunology·Sarah NersesianJeanette E Boudreau
May 26, 2018·Bone Marrow Transplantation·Katharina FleischhauerBronwen E Shaw
Jun 27, 2019·Leukemia & Lymphoma·Hannah K Choe, Koen van Besien
Jul 28, 2020·Immunological Medicine·Takero ShindoShinya Kimura
Jun 21, 2020·International Journal of Molecular Sciences·Sena KimJaebok Choi
Apr 1, 2020·Frontiers in Immunology·Ute V SollochJürgen Sauter
Aug 9, 2020·Molecular Cancer·Song-Yang WuZhi-Ming Shao
Apr 27, 2018·Cancer Immunology Research·Hiroshi UreshinoShinya Kimura
Feb 6, 2020·Cancer Immunology Research·Dana L Casey, Nai-Kong V Cheung
Nov 11, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nai-Kong Cheung, Katharine C Hsu
Feb 16, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marcel P TrefnyHeinz Läubli
Jan 7, 2021·The New England Journal of Medicine·Sherif S FaragShuhong Zhang
Jan 4, 2020·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Kentaro IdoHirohisa Nakamae
Feb 11, 2021·International Journal of Immunogenetics·Ann-Margaret LittlePaul A Wright
Oct 15, 2020·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Christine Camacho-BydumeKatharine C Hsu
Jun 13, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lisbeth A GuethleinPeter Parham

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.

Antibody Repertoire Diversity

Antibody repertoire diversity and its role during natural infection is a prerequisite for molecular and structural elucidation of functionally protective immunity. Discover the latest insights into antibody diversity here.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Related Papers

The New England Journal of Medicine
Jeffrey M VenstromKatharine C Hsu
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Katharine C HsuInternational Histocompatibility Working Group
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Nobuyoshi ArimaYoshinobu Kanda
© 2022 Meta ULC. All rights reserved