Kisspeptin and neurokinin B interactions in modulating gonadotropin secretion in women with polycystic ovary syndrome.

Human Reproduction
K SkorupskaiteR A Anderson

Abstract

What is the role of the hypothalamic neuropeptide neurokinin B (NKB) and its interaction with kisspeptin on GnRH/LH secretion in women with polycystic ovary syndrome (PCOS)? Administration of neurokinin 3 receptor antagonist (NK3Ra) for 7 days reduced LH and FSH secretion and LH pulse frequency in women with PCOS, whilst the stimulatory LH response to kisspeptin-10 was maintained. PCOS is characterized by abnormal GnRH/LH secretion. NKB and kisspeptin are master regulators of GnRH/LH secretion, but their role in PCOS is unclear. The NK3Ra MLE4901, 40 mg orally twice a day, was administered to women with PCOS for 7 days (n = 8) (vs no treatment, n = 7). On the last day of NK3Ra administration or the equivalent day in those not treated, women were randomized to 7-h kisspeptin-10 (4 µg/kg/h i.v.) or vehicle infusion. This was repeated with the alternate infusion in a subsequent cycle. Subjects were women with PCOS, studied in a Clinical Research Facility. Reproductive hormones were measured before and after NK3Ra administration. On the last day of NK3Ra administration (or the equivalent cycle day in untreated women), all women attended for an 8-h frequent blood sampling to allow analysis of the pulsatile LH secretion. NK3Ra reduce...Continue Reading

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Citations

Nov 19, 2020·The Journal of Clinical Endocrinology and Metabolism·Maria ForslundEva Dahlgren
Mar 22, 2021·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Faustino R Pérez-LópezGonzalo R Pérez-Roncero
Feb 25, 2021·The Journal of Clinical Endocrinology and Metabolism·Steve PawseyWaljit Singh Dhillo
Jul 18, 2021·Pharmacology & Therapeutics·Karolina Skorupskaite, Richard A Anderson
May 18, 2021·The Journal of Clinical Endocrinology and Metabolism·Graeme L FraserSteven Ramael
Aug 14, 2021·The Journal of Clinical Endocrinology and Metabolism·Elizabeth A McCarthyVictor M Navarro
Dec 29, 2021·Journal of Neuroendocrinology·Richard A Anderson, Robert P Millar
Jan 1, 2022·Journal of Neuroendocrinology·Stephanie B Seminara, A Kemal Topaloglu
Jan 28, 2022·Journal of Neuroendocrinology·Christopher R McCartneySuzanne M Moenter

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BETA
contraception
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Software Mentioned

GraphPad Prism

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