Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor alpha

Neuroscience Letters
I FranceschiniA Caraty

Abstract

Kisspeptins are peptide ligands of the G protein-coupled receptor GPR54, recently shown to be essential to reproductive function. We have raised specific rabbit antisera against a highly conserved 10 amino acid-amidated peptide (kp10) common to all kisspeptin isoforms isolated so far and mapped the distribution of kp10-immunoreactive (ir) cells in the ovine hypothalamus. Kp10-ir cells were predominant in the caudal arcuate nucleus, the dorsomedial nucleus and the medial preoptic area. Numerous varicose kp10-ir fibers were found in the preoptic area where GnRH neurons reside and in the median eminence, seemingly projecting around small capillaries in its external zone. Within the caudal arcuate nucleus, nearly all kp10-ir cells showed an intense estradiol receptor alpha immunofluorescent signal compared with approximately half of kp10-ir cells in the preoptic area. The pattern of distribution of kp10 immunoreactivity in the hypothalamus suggests a role for kisspeptin in the estrogen-dependent regulation of GnRH and LH secretion in the ewe.

References

Jan 1, 1988·Histochemistry·M CaldaniM P Dubois
Jan 1, 1980·Reproduction, Nutrition, Development·A CaratyM P Dubois
Oct 21, 1993·International Journal of Cancer. Journal International Du Cancer·T al SaatiG Delsol
Jun 2, 2001·The Journal of Biological Chemistry·A I MuirD C Harrison
Aug 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Nicolas de RouxEdwin Milgrom
Oct 24, 2003·The New England Journal of Medicine·Stephanie B SeminaraWilliam H Colledge
Dec 14, 2004·The Journal of Comparative Neurology·G Cristina BrailoiuNae J Dun
Jan 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Sophie MessagerSamuel A J R Aparicio
Feb 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·Muhammad ShahabTony M Plant
May 28, 2005·Endocrinology·Jeremy T SmithRobert A Steiner
Jul 26, 2005·Science·Gretchen Vogel

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Citations

Sep 28, 2012·Journal of Assisted Reproduction and Genetics·Kulvinder Kochar KaurMandeep Singh
Mar 6, 2007·Reviews in Endocrine & Metabolic Disorders·J T Smith, I J Clarke
Mar 24, 2007·Reviews in Endocrine & Metabolic Disorders·Florent G RevelValérie Simonneaux
Apr 26, 2011·Nature Neuroscience·Christian Mayer, Ulrich Boehm
Jul 3, 2013·Nature Reviews. Endocrinology·Robert P Millar, Claire L Newton
Oct 12, 2011·Proceedings of the National Academy of Sciences of the United States of America·Naoko InoueHiroko Tsukamura
Dec 26, 2008·Human Reproduction Update·A K Roseweir, R P Millar
Nov 1, 2009·Integrative and Comparative Biology·Wilbur P WilliamsLance J Kriegsfeld
Nov 9, 2007·Annual Review of Physiology·Simina M PopaRobert A Steiner
Oct 17, 2007·Neuroendocrinology·Y QiI J Clarke
Jan 15, 2009·Neuroendocrinology·Sheng Zhao, Lance J Kriegsfeld
Mar 25, 2010·Neuroendocrinology·Paul MicevychJohn Kuo
Sep 26, 2012·The Journal of Clinical Investigation·Charlotte SonigoNadine Binart
May 3, 2008·Endocrinology·Xavier d'Anglemont de TassignyWilliam H Colledge
Sep 20, 2012·Endocrinology·Robert L Goodman, Michael N Lehman
Sep 23, 2009·Endocrine Reviews·Amy E OakleyRobert A Steiner
Jul 9, 2011·PloS One·Mateusz ZajacMoshmi Bhattacharya
Mar 19, 2014·PloS One·Ling XiaoQun-Yong Zhou
May 23, 2014·PloS One·James S Kinsey-JonesKevin G Murphy
Jul 30, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Li-Ying Fu, Anthony N van den Pol
Nov 5, 2011·Yi chuan = Hereditas·Dong-Wei Huang, Ming-Xing Chu
Jun 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Xavier d'Anglemont de TassignyWilliam H Colledge
Feb 5, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·Sharon R Ladyman, Barbara Woodside
Aug 31, 2014·General and Comparative Endocrinology·Guangfu HuAnderson O L Wong

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