Kisspeptin signaling in the amygdala modulates reproductive hormone secretion.

Brain Structure & Function
Alexander N ComninosWaljit S Dhillo

Abstract

Kisspeptin (encoded by KISS1) is a crucial activator of reproductive function. The role of kisspeptin has been studied extensively within the hypothalamus but little is known about its significance in other areas of the brain. KISS1 and its cognate receptor are expressed in the amygdala, a key limbic brain structure with inhibitory projections to hypothalamic centers involved in gonadotropin secretion. We therefore hypothesized that kisspeptin has effects on neuronal activation and reproductive pathways beyond the hypothalamus and particularly within the amygdala. To test this, we mapped brain neuronal activity (using manganese-enhanced MRI) associated with peripheral kisspeptin administration in rodents. We also investigated functional relevance by measuring the gonadotropin response to direct intra-medial amygdala (MeA) administration of kisspeptin and kisspeptin antagonist. Peripheral kisspeptin administration resulted in a marked decrease in signal intensity in the amygdala compared to vehicle alone. This was associated with an increase in luteinizing hormone (LH) secretion. In addition, intra-MeA administration of kisspeptin resulted in increased LH secretion, while blocking endogenous kisspeptin signaling within the amygd...Continue Reading

References

Mar 1, 1970·The American Journal of Physiology·I E Lawton, C H Sawyer
Nov 1, 1966·The American Journal of Physiology·M Bar-Sela, V Critchlow
Sep 18, 1995·The Journal of Comparative Neurology·N S CanterasL W Swanson
Feb 3, 1998·The Journal of Neuropsychiatry and Clinical Neurosciences·H Klüver, P C Bucy
Apr 1, 1999·FEBS Letters·D K LeeB F O'Dowd
Jun 2, 2001·The Journal of Biological Chemistry·A I MuirD C Harrison
Aug 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Nicolas de RouxEdwin Milgrom
Oct 24, 2003·The New England Journal of Medicine·Stephanie B SeminaraWilliam H Colledge
Sep 22, 2005·The Journal of Clinical Endocrinology and Metabolism·Waljit S DhilloStephen R Bloom
Dec 13, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Seong-Kyu HanAllan E Herbison
Aug 19, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alexander S KauffmanEmilie F Rissman
Nov 9, 2007·Trends in Cognitive Sciences·Elisabeth A Murray
Nov 9, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yu-Ting KuoJimmy D Bell
Feb 15, 2008·The New England Journal of Medicine·Milena Gurgel TelesAna Claudia Latronico
Jun 14, 2008·Schizophrenia Bulletin·Afonso C Silva, Nicholas A Bock
Jun 12, 2009·Journal of Neuroendocrinology·J ClarksonA E Herbison
Nov 26, 2009·American Journal of Physiology. Endocrinology and Metabolism·Annette E CurtisKevin G Murphy
Mar 20, 2010·The Journal of Clinical Endocrinology and Metabolism·L G SilveiraA C Latronico
Jun 25, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xavier d'Anglemont de TassignyWilliam H Colledge
Mar 3, 2011·General and Comparative Endocrinology·Dhan Chand, David A Lovejoy
Mar 3, 2011·Endocrinology·Joshua KimAlexander S Kauffman
Aug 4, 2011·Endocrinology·Victoria Scott, Colin H Brown
Oct 7, 2011·The Journal of Clinical Endocrinology and Metabolism·Channa N JayasenaWaljit S Dhillo
Jan 21, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Naresh Kumar HanchateVincent Prevot
Feb 18, 2012·The New England Journal of Medicine·A Kemal TopalogluBilgin Yuksel
Jul 20, 2012·Physiological Reviews·Leonor PinillaManuel Tena-Sempere
Sep 27, 2012·American Journal of Physiology. Endocrinology and Metabolism·David García-GalianoManuel Tena-Sempere

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Citations

Jul 21, 2015·Medical Hypotheses·Dori PitynskiDonal C Skinner
May 29, 2016·Neuroscience Letters·Rebecca GreshamKevin T O'Byrne
Aug 2, 2016·The Journal of Reproduction and Development·Yoshihisa UenoyamaKei-Ichiro Maeda
Apr 6, 2018·Cellular and Molecular Life Sciences : CMLS·Lisa YangWaljit S Dhillo
Jul 17, 2018·Endocrinology·Aleisha M MooreMichael N Lehman
May 28, 2019·The Journal of Clinical Endocrinology and Metabolism·Margaret F LippincottStephanie Beth Seminara
Aug 22, 2017·Frontiers in Endocrinology·Shannon B Z Stephens, Alexander S Kauffman
Aug 29, 2017·PloS One·Daniel A AdekunbiKevin T O'Byrne
Mar 28, 2019·PloS One·Shel-Hwa YeoWilliam Henry Colledge
Jun 2, 2016·Endocrinology and Metabolism·Xinhuai Liu, Allan E Herbison
Jan 23, 2018·Frontiers in Endocrinology·Kai-Lun HuJie Qiao
Oct 12, 2018·The Journal of Endocrinology·Edouard G A MillsAlexander N Comninos
Nov 17, 2020·Expert Opinion on Drug Safety·Marie GombertAna M Peiró
Aug 14, 2019·Genomics·Meiyao WangZhixiang Zhu
Jan 28, 2021·Proceedings of the National Academy of Sciences of the United States of America·Mayuko NagaeHiroko Tsukamura
May 12, 2021·Psychoneuroendocrinology·Alexander N ComninosWaljit S Dhillo
Apr 27, 2021·Endocrine Reviews·Edouard G MillsAlexander N Comninos
Sep 15, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·Ushodaya MattamNaresh Babu V Sepuri

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