Kit and FcepsilonRI mediate unique and convergent signals for release of inflammatory mediators from human mast cells.

Blood
Thomas R HundleyM A Beaven

Abstract

In human mast cells, derived from CD34(+) peripheral blood cells, we observed that Kit ligand (KL) failed to induce degranulation but acted in synergy with antigen to markedly enhance degranulation, levels of cytokine gene transcripts, and production of cytokines. Further examination revealed that antigen and KL activated common and unique signaling pathways to account for these varied responses. KL, unlike antigen, failed to activate protein kinase C but activated phospholipase Cgamma and calcium mobilization and augmented these signals as well as degranulation when added together with antigen. Both KL and antigen induced signals that are associated with cytokine production, namely phosphorylation of the mitogen-activated protein kinases, phosphatidylinositol 3-kinase-dependent phosphorylation of protein kinase B (also known as Akt), and phosphorylation of nuclear factor kappaB (NFkappaB). However, only KL stimulated phosphorylation of signal transducer and activator of transcription 5 (STAT5) and STAT6, whereas antigen weakly stimulated the protein kinase C-dependent induction and phosphorylation of c-Jun and associated activating protein-1 (AP-1) components, an action that was markedly potentiated by costimulation with KL. I...Continue Reading

References

Jan 1, 1992·The Journal of Experimental Medicine·S C Bischoff, C A Dahinden
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M TsaiS J Galli
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A Wodnar-Filipowicz, C Moroni
Jul 15, 1990·The Biochemical Journal·M M Billah, J C Anthes
Aug 2, 1994·Proceedings of the National Academy of Sciences of the United States of America·E RazinJ Rivera
May 12, 1994·Nature·J M KyriakisJ R Woodgett
May 1, 1993·Immunology Today·M A Beaven, H Metzger
Dec 5, 1998·Biochimica Et Biophysica Acta·M J Wakelam
Jan 19, 1999·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·C PelletierU Blank
May 4, 1999·International Archives of Allergy and Immunology·T BaumrukerE E Prieschl
Dec 3, 1999·The International Journal of Biochemistry & Cell Biology·D Linnekin
Dec 22, 1999·The Journal of Immunology : Official Journal of the American Association of Immunologists·A LorentzS C Bischoff
Mar 17, 2000·The Journal of Allergy and Clinical Immunology·D L Marquardt, L L Walker
May 23, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M StassenE Schmitt
Jul 26, 2000·Hematology/oncology Clinics of North America·M L Taylor, D D Metcalfe
Mar 14, 2001·Trends in Biochemical Sciences·M L SchmitzM Kracht
Mar 20, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y OkayamaD D Metcalfe
Mar 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·K ChayamaE W Gelfand
May 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C Chaves-DiasM A Beaven
Dec 26, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ravi Malaviya, Fatih M Uckun
Apr 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Janet KalesnikoffGerald Krystal
May 4, 2002·Nature Cell Biology·Eitan Shaulian, Michael Karin
Jul 3, 2002·Nature Reviews. Cancer·Igor Vivanco, Charles L Sawyers
Oct 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·William R CowardMartin K Church
Nov 5, 2002·Current Opinion in Immunology·Juan Rivera
Dec 24, 2002·The Biochemical Journal·Alexandra C Newton

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Citations

Jun 18, 2009·Seminars in Immunopathology·Stephan C Bischoff
Oct 2, 2008·Immunologic Research·Alasdair M GilfillanDean D Metcalfe
Feb 4, 2014·Pharmacology & Therapeutics·Laurent L Reber, Nelly Frossard
Feb 14, 2006·Nature Reviews. Immunology·Alasdair M Gilfillan, Christine Tkaczyk
Oct 11, 2007·The Journal of Pharmacology and Experimental Therapeutics·Bettina M JensenAlasdair M Gilfillan
Jan 14, 2012·Endocrine Reviews·Jia-Ming Xu, Guo-Ping Shi
Jun 9, 2006·Immunologic Research·Yoshimichi Okayama, Toshiaki Kawakami
Jun 6, 2009·Critical Reviews in Immunology·Hong-Tao Ma, Michael A Beaven
Feb 11, 2012·Critical Reviews in Immunology·Alasdair M Gilfillan, Michael A Beaven
Oct 20, 2006·Proceedings of the National Academy of Sciences of the United States of America·Poulami MitraSarah Spiegel
Jun 11, 2010·Genes and Immunity·J K MoralesJ J Ryan
Jan 30, 2013·Journal of Immunological Methods·Daniel SmržAlasdair M Gilfillan
Aug 11, 2015·European Journal of Immunology·Geethani BandaraDean D Metcalfe
Jan 18, 2016·The Journal of Allergy and Clinical Immunology·Avanti DesaiDean D Metcalfe
Oct 2, 2007·Dermatologic Clinics·Michihiro HideMalcolm W Greaves
Oct 9, 2007·Immunology Letters·Hye Sun Kuehn, Alasdair M Gilfillan
Jul 13, 2007·Trends in Immunology·Ido Bachelet, Francesca Levi-Schaffer
Aug 26, 2006·Immunology and Allergy Clinics of North America·Christine TkaczykAlasdair M Gilfillan
Nov 17, 2009·Immunological Reviews·Damiana Alvarez-ErricoJuan Rivera
Nov 17, 2009·Immunological Reviews·Taku KambayashiGary A Koretzky
Mar 18, 2009·Immunological Reviews·Alasdair M Gilfillan, Juan Rivera
Jun 9, 2007·British Journal of Haematology·Alberto OrfaoUNKNOWN REMA
Sep 20, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Grazyna GalatowiczVirginia L Calder
Jun 28, 2013·Experimental Dermatology·Brian C Wulff, Traci A Wilgus
Nov 22, 2011·Cytometry. Part B, Clinical Cytometry·Marjoke M VerweijDidier G Ebo
Jan 3, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A LewisP T Peachell
May 31, 2013·European Journal of Immunology·Michael Huber
Mar 3, 2011·The FEBS Journal·Wilfried EllmeierAlexandra Schebesta

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