Kiwi fruit (Actinidia chinensis L.) polysaccharides exert stimulating effects on cell proliferation via enhanced growth factor receptors, energy production, and collagen synthesis of human keratinocytes, fibroblasts, and skin equivalents

Journal of Cellular Physiology
Alexandra DetersAndreas Hensel

Abstract

Within physiological engineering exogenous carbohydrates were recently confirmed as pharmacologically active compounds. To investigate potential dermatological activity purified polysaccharides from kiwi fruits (Actinidia chinensis L., Actinidiaceae) were characterized concerning monomer composition, linkage types and molecular weights and were tested under in vitro conditions for regulating activities on cell physiology of human keratinocytes, fibroblasts, and skin equivalents. Ten micrograms per milliliter of raw polysaccharide, neutral type-II-arabinogalactans, and acidic arabinorhamnogalacturonans of kiwi fruits stimulated cell proliferation of human keratinocytes (NHK, HaCaT) up to 30% significantly while mitochondrial activity was stimulated for nearly 25% in regard to control cells. Fibroblasts were not as sensitive as keratinocytes but >130 microg/ml kiwi fruit polysaccharides increased proliferation and ATP-synthesis significantly, too. Proliferation-stimulating activity was dependent on terminal 1-alpha-l-arabinose residues since enzymatic release of these sugar moieties caused significantly decreased proliferation of HaCaT and fibroblasts of about 10% in regard to untreated cells. In three dimensional skin equivalent...Continue Reading

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Citations

Sep 10, 2014·Journal of Tissue Viability·Fatma BouazizSemia Ellouz Chaabouni
Jul 26, 2005·Journal of Ethnopharmacology·P J HoughtonA M Deters
May 24, 2016·International Journal of Biological Macromolecules·Chuner CaiPeimin He
Jul 23, 2016·Environmental Geochemistry and Health·Eliana SpiliotiParaskevi Moutsatsou
Oct 14, 2016·Journal of Cellular Physiology·Abderrakib ZahidMarie-Laure Follet-Gueye
Jun 19, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vincent GloaguenYann Guerardel
Jul 20, 2007·The Journal of Pharmacy and Pharmacology·N WittschierA Hensel
Nov 19, 2019·Frontiers in Pharmacology·Xirui HeLinhong Huang
Apr 23, 2020·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Sophia LetsiouJamal Ouazzani

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