Klebsiella pneumoniae: a major worldwide source and shuttle for antibiotic resistance

FEMS Microbiology Reviews
S Navon-VeneziaAlessandra Carattoli

Abstract

Klebsiella pneumoniae is an important multidrug-resistant (MDR) pathogen affecting humans and a major source for hospital infections associated with high morbidity and mortality due to limited treatment options. We summarize the wide resistome of this pathogen, which encompasses plentiful chromosomal and plasmid-encoded antibiotic resistance genes (ARGs). Under antibiotic selective pressure, K. pneumoniae continuously accumulates ARGs, by de novo mutations, and via acquisition of plasmids and transferable genetic elements, leading to extremely drug resistant (XDR) strains harboring a 'super resistome'. In the last two decades, numerous high-risk (HiR) MDR and XDR K. pneumoniae sequence types have emerged showing superior ability to cause multicontinent outbreaks, and continuous global dissemination. The data highlight the complex evolution of MDR and XDR K. pneumoniae, involving transfer and spread of ARGs, and epidemic plasmids in highly disseminating successful clones. With the worldwide catastrophe of antibiotic resistance and the urgent need to identify the main pathogens that pose a threat on the future of infectious diseases, further studies are warranted to determine the epidemic traits and plasmid acquisition in K. pneu...Continue Reading

References

Jan 1, 1987·The Journal of Antimicrobial Chemotherapy·H KnotheV Krcméry
Dec 1, 1988·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J A van de KlundertS de Marie
Aug 1, 1985·Antimicrobial Agents and Chemotherapy·C KliebeB Wiedemann
Nov 1, 1969·Journal of Clinical Pathology·B DavisE J Lowbury
Jan 1, 1973·Annual Review of Biochemistry·R Benveniste, J Davies
Jun 1, 1983·European Journal of Clinical Microbiology·J G GuerraE Antunez de Mayolo
Feb 1, 1980·Molecular & General Genetics : MGG·R KollekW Goebel
Dec 1, 1983·The Journal of Antimicrobial Chemotherapy·J D Baumgartner, M P Glauser
Jan 1, 1994·Scandinavian Journal of Infectious Diseases·J RydbergH Miörner
Mar 31, 1998·Lancet·L Martínez-MartínezG A Jacoby
Aug 22, 2000·Antimicrobial Agents and Chemotherapy·S HarutaT Sawai
Sep 15, 2001·Antimicrobial Agents and Chemotherapy·J ChavesC Ampurdanés
Nov 19, 2002·Antimicrobial Agents and Chemotherapy·Annarita MazzariolRoberta Fontana
Mar 5, 2003·The Journal of Antimicrobial Chemotherapy·Ellen Smith MolandKenneth S Thomson
Mar 26, 2003·Antimicrobial Agents and Chemotherapy·Vivi MiriagouJean M Whichard
Jul 25, 2003·Antimicrobial Agents and Chemotherapy·Marc GalimandThierry Lambert
Nov 23, 1963·British Medical Journal·J F WARD-MCQUAIDR MACIS
Dec 25, 2003·Antimicrobial Agents and Chemotherapy·Laurent PoirelPatrice Nordmann
Oct 27, 2004·Antimicrobial Agents and Chemotherapy·Ashfaque HossainN D Hanson
Apr 13, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Matthew E Falagas, Sofia K Kasiakou
Jun 7, 2005·Journal of Microbiological Methods·Alessandra CarattoliE John Threlfall
Jul 16, 2005·The Journal of Antimicrobial Chemotherapy·Patrice Nordmann, Laurent Poirel
Aug 6, 2005·Journal of Clinical Microbiology·Laure DiancourtSylvain Brisse
Aug 27, 2005·The Journal of Antimicrobial Chemotherapy·David M Livermore
Oct 4, 2005·Plasmid·Kurt Nordström
Aug 1, 2006·Trends in Microbiology·David M Livermore, Neil Woodford
Aug 31, 2006·Antimicrobial Agents and Chemotherapy·Shiri Navon-VeneziaYehuda Carmeli
Dec 6, 2006·Antimicrobial Agents and Chemotherapy·Ellen Smith MolandNancy D Hanson
Jan 31, 2007·Antimicrobial Agents and Chemotherapy·Maria Virginia VillegasUNKNOWN Colombian Nosocomial Resistance Study Group
Feb 6, 2007·Nature Reviews. Microbiology·Gerard D Wright
Feb 20, 2007·The Journal of Antimicrobial Chemotherapy·Anastasia AntoniadouHelen Giamarellou
Mar 8, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Simona BratuJohn Quale
Mar 21, 2007·The Journal of Biological Chemistry·Abigail ClementsRichard A Strugnell
Jul 17, 2007·Clinical Microbiology Reviews·Anne Marie Queenan, Karen Bush
Oct 6, 2007·Biological & Pharmaceutical Bulletin·Yu PingTomofusa Tsuchiya
Dec 12, 2007·Antimicrobial Agents and Chemotherapy·Christian G GiskeUNKNOWN ReAct-Action on Antibiotic Resistance
Dec 25, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·L Martínez-Martínez

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Citations

May 10, 2017·FEMS Microbiology Reviews·Ehud BaninOscar P Kuipers
Feb 2, 2018·Frontiers in Microbiology·Juan J González-PlazaNikolina Udiković-Kolić
Mar 6, 2018·The Journal of Antimicrobial Chemotherapy·Bruce L GellerDavid E Greenberg
Mar 25, 2018·Journal of Digestive Diseases·Christina Parvinder KaurSamudi Chandramathi
Feb 21, 2018·Journal of Medical Microbiology·Ying LiXinzhuo Zhang
Oct 3, 2018·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Shadi AghamohammadFereshteh Shahcheraghi
Nov 18, 2018·The Journal of Antimicrobial Chemotherapy·Miranda E PittMatthew A Cooper
Nov 14, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Qi WangHui Wang
Nov 2, 2018·Microbial Genomics·Sergio Arredondo-AlonsoAnita C Schürch
May 11, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Bruna FugaRosineide Marques Ribas
Apr 5, 2019·Journal of Clinical Microbiology·Cátia MarquesConstança Pomba
Oct 11, 2017·Acta Crystallographica. Section F, Structural Biology Communications·Bjarte Aarmo LundHanna Kirsti S Leiros
Oct 11, 2019·Scientific Reports·Abu Sayed ChowdhuryShira L Broschat
Jan 11, 2020·Annals of Clinical Microbiology and Antimicrobials·Clement Yaw EffahYongjun Wu
Mar 10, 2020·Microbial Genomics·Floriana GonaDaniela Maria Cirillo
Mar 11, 2020·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Nadezhda K FursovaNikolay V Volozhantsev
Mar 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Do N DaiWilliam N Setzer
Apr 7, 2020·Nature Ecology & Evolution·Hannah JordtBenjamin Kerr
Oct 12, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Ferielle Mesbah ZekarYves Millemann
Dec 10, 2019·Acta Microbiologica Et Immunologica Hungarica·Alicja SękowskaEugenia Gospodarek-Komkowska
Jun 7, 2019·Microbiology Resource Announcements·Mutshiene Deogratias EkwanzalaMaggy Ndombo Benteke Momba
May 21, 2020·Viruses·Cindy M SpruitMaria I Pajunen
Jan 3, 2020·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Isabel CarvalhoPatrícia Poeta
May 28, 2020·ChemMedChem·Maria Luisa IntrovigneRobert A Bonomo

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