Klebsiella pneumoniae FimK Promotes Virulence in Murine Pneumonia

The Journal of Infectious Diseases
David A RosenDavid A Hunstad

Abstract

Klebsiella pneumoniae, a chief cause of nosocomial pneumonia, is a versatile and commonly multidrug-resistant human pathogen for which further insight into pathogenesis is needed. We show that the pilus regulatory gene fimK promotes the virulence of K. pneumoniae strain TOP52 in murine pneumonia. This contrasts with the attenuating effect of fimK on urinary tract virulence, illustrating that a single factor may exert opposing effects on pathogenesis in distinct host niches. Loss of fimK in TOP52 pneumonia was associated with diminished lung bacterial burden, limited innate responses within the lung, and improved host survival. FimK expression was shown to promote serum resistance, capsule production, and protection from phagocytosis by host immune cells. Finally, while the widely used K. pneumoniae model strain 43816 produces rapid dissemination and death in mice, TOP52 caused largely localized pneumonia with limited lethality, thereby providing an alternative tool for studying K. pneumoniae pathogenesis and control within the lung.

References

Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S D WolpeA Cerami
Aug 1, 1973·Analytical Biochemistry·N Blumenkrantz, G Asboe-Hansen
Nov 25, 2003·American Journal of Respiratory and Critical Care Medicine·Mark L MeterskyPeter M Houck
Feb 24, 2004·Infection and Immunity·Sunita Shankar-SinhaJohn G Younger
May 15, 2004·Environmental Microbiology·Carsten Struve, Karen Angeliki Krogfelt
Jun 19, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David L PatersonVictor L Yu
Jul 24, 2004·Infection and Immunity·Heather F LavenderSteven Clegg
Sep 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jane C DengTheodore J Standiford
Oct 16, 2004·Immunity·Jay K Kolls, Anders Lindén
Nov 24, 2004·Infection and Immunity·Miguel A CamposJosé A Bengoechea
Jul 26, 2005·Infection and Immunity·Mark A SchembriPer Klemm
Sep 6, 2005·Research in Microbiology·Nathalie MaroncleChristiane Forestier
Nov 3, 2005·Molecular Microbiology·Matthew S LawlorVirginia L Miller
Apr 19, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Wen-Liang YuYin-Ching Chuang
Aug 24, 2006·Infection and Immunity·Matthew S LawlorVirginia L Miller
Jul 23, 2008·Infection and Immunity·David A RosenScott J Hultgren
Nov 19, 2008·Infection and Immunity·Ann CraigSamithamby Jeyaseelan
Nov 19, 2008·Antimicrobial Agents and Chemotherapy·Enrique LlobetJosé A Bengoechea
Nov 26, 2008·Nature Reviews. Immunology·David M Mosser, Justin P Edwards
Mar 17, 2009·Nature Reviews. Microbiology·Regine Hengge
Aug 1, 2009·Nature Protocols·Chia-Suei HungScott J Hultgren
Jul 13, 2011·Antimicrobial Agents and Chemotherapy·Vinod KumarJames R Brown
May 25, 2013·Microbiology·Zhe-Chong WangHwei-Ling Peng
Aug 24, 2013·The Lancet Infectious Diseases·L Silvia Munoz-PriceJohn P Quinn
Sep 27, 2013·International Journal of Immunopathology and Pharmacology·I SantinoA Alari
Mar 7, 2014·Infection and Immunity·Lauren E DeadySharon Celeste Morley
Mar 8, 2014·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Clare RockDaniel J Morgan
Jul 6, 2014·Genome Announcements·Jeremiah G JohnsonJyl S Matson

❮ Previous
Next ❯

Citations

Nov 22, 2017·Infection and Immunity·David A RosenDavid A Hunstad
Jun 17, 2016·Microbiology and Molecular Biology Reviews : MMBR·Michelle K Paczosa, Joan Mecsas
Mar 6, 2019·Scientific Reports·Jillian L PopeChristian Jobin
Dec 29, 2020·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Zhiqiang YangKui Zhu
Jan 23, 2021·International Wound Journal·Sareeen FatimaAdnan Khan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

© 2021 Meta ULC. All rights reserved