PMID: 8586786Nov 1, 1995Paper

Klebsiella pneumoniae infections in Greek hospitals. Dissemination of plasmids encoding an SHV-5 type beta-lactamase

The Journal of Hospital Infection
N J LegakisA C Vatopoulos

Abstract

A total of 160 Klebsiella pneumoniae clinical strains consecutively isolated in 14 Greek hospitals in a three-month period was examined. Application of capsular typing using 72 monovalent antisera combined with phage-typing using a set of 15 Klebsiella-specific phages showed the absence of epidemic strains. However, 41% of the isolates examined displayed high level resistance to ceftazidime and aztreonam and, in most of the cases, to more than one aminoglycoside as well as to other antibacterial drugs. Nearly all of these multi-resistant strains were epidemiologically distinct on the basis of their capsular serotype and phage reactivity. After examination of 14 distinct strains, it was found that in nine cases, the resistance characters were readily transferred to Escherichia coli recipients through large self-transmissible plasmids (15-100 MDa). Six of the nine plasmids had equal molecular weight (60 MDa) and displayed similar fragment profiles upon digestion with restriction endonuclease EcoRI. Isoelectric focusing and hydrolytic studies showed that the prominent beta-lactamase produced by the transconjugants harbouring the 60 MDa plasmids and the respective K. pneumoniae parent strains, was an extended-spectrum beta-lactamas...Continue Reading

References

Sep 1, 1978·Journal of Clinical Pathology·M Casewell, I Phillips
Nov 1, 1990·The Journal of Hospital Infection·B Ayling-Smith, T L Pitt
Nov 1, 1990·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·G ArletA Philippon
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Jul 1, 1993·The Journal of Hospital Infection·N J LegakisA C Vatopoulos

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Citations

Jan 1, 1997·International Journal of Antimicrobial Agents·L S TzouvelekisN J Legakis
Dec 10, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J C LucetB Régnier
Jul 17, 2004·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Thouraya Ben-HamoudaKamel Ben-Mahrez
Jan 1, 1995·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·N J LegakisL S Tzouvelekis
May 25, 2004·Antimicrobial Agents and Chemotherapy·Laurent PoirelPatrice Nordmann
Oct 15, 2005·Clinical Microbiology Reviews·David L Paterson, Robert A Bonomo
Apr 28, 2011·Journal of Environmental Sciences (China)·Dongdong ZhangZongjun Cui
Oct 8, 1999·The Journal of Antimicrobial Chemotherapy·J HeritageP M Hawkey
Feb 12, 1998·Journal of Clinical Microbiology·L S TzouvelekisN J Legakis
Feb 1, 1997·Journal of Clinical Microbiology·M GazouliL S Tzouvelekis

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