KLF10, transforming growth factor-β-inducible early gene 1, acts as a tumor suppressor

Biochemical and Biophysical Research Communications
Ki-Duk SongWoon-Kyu Lee

Abstract

Krüppel-like factor 10 (KLF10) has been suggested to be a putative tumor suppressor. In the present study, we generated KLF10 deficient mice to explore this hypothesis in vivo. KLF10 deficient mice exhibited increased predisposition to skin tumorigenesis and markedly accelerated papilloma development after DMBA/TPA treatment. On the other hand, KLF10 deficient keratinocytes showed increased proliferation and apoptosis. In colony formation assays after oncogenic H-Ras transfection, KLF10 deficient mouse embryonic fibroblasts (MEFs) yielded more colonies than wild-type MEFs. Furthermore, KLF10 dose-dependently activated p21(WAF1/CIP1) transcription, which was independent of p53 and Sp1 binding sites in p21(WAF1/CIP1) promoter. This study demonstrates that KLF10 is a tumor suppressor and that it targets p21(WAF1/CIP1) transcription.

References

Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·K BrownA Balmain
Nov 19, 1993·Cell·W S el-DeiryB Vogelstein
Jun 26, 2001·Journal of Cellular Physiology·A R BlackJ Azizkhan-Clifford
Jun 26, 2004·Breast Cancer Research and Treatment·Monica M ReinholzThomas C Spelsberg
Jun 24, 2006·Nature Reviews. Cancer·Brian Bierie, Harold L Moses
Aug 5, 2006·Journal of Cellular Biochemistry·Nalini M RajamannanThomas C Spelsberg
Oct 13, 2006·Current Opinion in Gastroenterology·V EllenriederR Urrutia
Jul 6, 2007·Oncology Reports·Vahe Michael ZohrabianMeena Jhanwar-Uniyal
May 29, 2008·Molecular and Cellular Biology·Kristina EllwangerChristof Niehrs

❮ Previous
Next ❯

Citations

May 28, 2013·Journal of Dermatological Science·Chang-Joon BaeWoon-Kyu Lee
Jan 22, 2017·The Journal of Investigative Dermatology·Zhi-Cheng HuBing Tang
Jan 21, 2017·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Vincent Hung-Shu ChangHui-Ju Ch'ang
Jan 24, 2016·Biochemical and Biophysical Research Communications·Malayannan SubramaniamJohn R Hawse
Sep 26, 2013·Nature Reviews. Cancer·Marie-Pier TetreaultJonathan P Katz
Mar 8, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jong Min LeeGun-Il Im
Mar 16, 2018·Frontiers in Immunology·Girak KimCheol-Heui Yun
May 26, 2018·Cancers·Azra Memon, Woon Kyu Lee
Nov 26, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wei-An ChangPo-Lin Kuo
Jan 6, 2021·International Journal of Molecular Sciences·Junghoon LeeJi-Young Cha

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Hiranmoy DasMukesh K Jain
The Journal of Biological Chemistry
Anne HamikMukesh K Jain
The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology
Lei JiangHsiang-fu Kung
© 2022 Meta ULC. All rights reserved