KLF5 promotes cell migration by up-regulating FYN in bladder cancer cells

FEBS Letters
Chong DuPeng Guo

Abstract

Krüppel-like factor 5 (KLF5) promotes cell proliferation of bladder cancer. However, whether KLF5 regulates other cell processes in bladder cancer is not clear. We found that KLF5 increases cell migration and lamellipodia formation, expression of FYN and phosphorylation of FAK in bladder cancer cells. In addition, KLF5 promotes transcription of FYN through binding to its promoter. FYN overexpression rescues cell migration and lamellipodia formation reduced by KLF5 knockdown. Furthermore, the KLF5/FYN/p-FAK axis is necessary for lysophosphatidic acid (LPA) to promote cell migration. Our findings indicate that both KLF5 and FYN are important in the regulation of cell migration in bladder cancer cells. We propose the KLF5/FYN/p-FAK axis as a potential therapeutic target in bladder cancer.

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Citations

Jun 18, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Weiwei WangChunbin Wang
Oct 28, 2018·Journal of Cellular Physiology·Taicheng ZhouXiaoyun Mao
Sep 15, 2018·Experimental and Therapeutic Medicine·Wandan ZhouBin Liu
Aug 17, 2018·Experimental and Therapeutic Medicine·Yanlan OuyangSainan Qiu
Jan 27, 2019·Experimental and Therapeutic Medicine·Lei ChenYunying Zhong
Apr 4, 2021·Cancer Science·Yao Luo, Ceshi Chen
Jul 22, 2021·Cancer Management and Research·Yuanchun LiWeihua Fu
Nov 2, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ying ZhangSei Kobayashi

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