Klinefelter's syndrome presenting with leg ulcers

Skinmed
Helena Martinez De MorentinSarah Brenner

Abstract

A 54-year-old man of Persian origin presented to our department with a 1-year history of ulcers on the right leg that had been unresponsive to numerous topical treatments, accompanied by lymphedema of the right leg. Medical history included hypergonadotropic hypogonadism, which had not been further investigated. He was treated for 20 years with testosterone IM once monthly, which he stopped a year before the current hospitalization for unclear reasons. The patient reported no congenital lymphedema. Physical examination revealed two deep skin ulcers (Figure 1) on the right leg measuring 10 cm in diameter with raised irregular inflammatory borders and a boggy, necrotic base discharging a purulent hemorrhagic exudate. Bilateral leg pitting edema and right lymphangitis with lymphadenitis were noted. He had low head hair implantment, sparse hair on the body and head, hyperpigmentation on both legs, onychodystrophia of the toenails (mainly the large toe and less prominent on the other toes), which was atrophic lichen-planus-like in appearance and needed no trimming (Figure 2), normal hand nails, oral thrush, and angular cheilitis. Other physical findings were gynecomastia, pectus excavatum, small and firm testicles, long extremities,...Continue Reading

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Citations

May 6, 2014·Annales d'endocrinologie·Eberhard NieschlagMichael Zitzmann
Oct 20, 2010·Nature Reviews. Endocrinology·Alexandra M MolnarJohn K Amory
Apr 27, 2012·Journal des maladies vasculaires·B VillemurM-P De Angelis
Jul 10, 2007·Skinmed·Ilan GoldbergSarah Brenner
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Aug 19, 2020·The Journal of Clinical Endocrinology and Metabolism·Tharu TharakanChanna Jayasena

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