KLK5 gene expression is severely upregulated in androgen-independent prostate cancer cells after treatment with the chemotherapeutic agents docetaxel and mitoxantrone

Biological Chemistry
Konstantinos MavridisAndreas Scorilas

Abstract

Kallikrein-related peptidases (KLKs), including KLK5, have been proposed as promising biomarkers for prostate cancer diagnosis and prognosis. In the present study, we report that distinct augmentations (up to 6.4-fold) of KLK5 mRNA expressional levels, calculated via quantitative real-time PCR, occur after treatment of DU145 cells with appropriate concentrations, determined by the MTT method, of docetaxel and mitoxantrone. Our data reveal the endogenous need of prostate cancer cells for modified KLK5 expression to cope with the administration of chemotherapeutic drugs. Furthermore, it is proposed that the expression profile of KLK5 could serve as a putative biomarker for monitoring the treatment response in hormone refractory prostate cancer patients.

References

Aug 6, 2000·Cell and Tissue Research·E M Bruckheimer, N Kyprianou
Aug 15, 2000·The Journal of Biological Chemistry·M P BolandL A O'Neill
Sep 28, 2000·Biochemical and Biophysical Research Communications·G M YousefE P Diamandis
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Apr 12, 2002·The Prostate·George M YousefEleftherios P Diamandis
Jul 22, 2004·American Journal of Therapeutics·James Gulley, William L Dahut
May 25, 2005·Cancer Letters·Christina V Obiezu, Eleftherios P Diamandis
Sep 17, 2005·CA: a Cancer Journal for Clinicians·Kenneth J Pienta, David C Smith
Jun 28, 2006·Biological Chemistry·Miltiadis Paliouras, Eleftherios P Diamandis
Jul 4, 2006·International Journal of Radiation Oncology, Biology, Physics·Rex CheungDeborah A Kuban
Dec 2, 2006·Nature Clinical Practice. Oncology·Mark T FlemingHoward I Scher
Feb 14, 2007·Prostate Cancer and Prostatic Diseases·E RichterA Dobi
Feb 17, 2007·Cancer Letters·Mark A ReynoldsHarry Rittenhouse
Sep 11, 2007·Urologic Oncology·Boris A Hadaschik, Martin E Gleave
Sep 11, 2007·European Urology·Richard J Bryant, Freddie C Hamdy
Nov 28, 2007·Annual Review of Pathology·Scott A TomlinsArul M Chinnaiyan
Dec 21, 2007·The Journal of Pathology·M J DuffyW M Gallagher
Mar 18, 2008·Cellular and Molecular Life Sciences : CMLS·A Lundwall, M Brattsand
Jun 13, 2008·Nature Protocols·Thomas D Schmittgen, Kenneth J Livak
Aug 9, 2008·Clinical Chemistry·Nashmil Emami, Eleftherios P Diamandis
Feb 5, 2009·Thrombosis and Haemostasis·Manfred Schmitt, Viktor Magdolen
Feb 25, 2009·Prostate Cancer and Prostatic Diseases·H Van PoppelR Oyen
Apr 14, 2009·Current Opinion in Oncology·Kiran Lassi, Nancy A Dawson
Oct 13, 2009·The Journal of Biological Chemistry·Georgia SotiropoulouEleftherios P Diamandis

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Citations

Sep 6, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Dimitra FlorouAndreas Scorilas
Oct 23, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Georgia PapachristopoulouAndreas Scorilas
Apr 20, 2010·Biological Chemistry·Viktor MagdolenHans Fritz
Apr 11, 2015·Expert Opinion on Investigational Drugs·Vittore CeredaMario Roselli
Feb 6, 2014·Urologic Oncology·Javier Romero OteroKarim A Touijer
May 9, 2014·BioMed Research International·Sung Kyu Hong
Feb 14, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Fabien GueugnonYves Courty

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