Klotho is upregulated in human cardiomyopathy independently of circulating Klotho levels

Scientific Reports
G PoelzlM M Zaruba

Abstract

Klotho is an antiaging protein which exerts known cardioprotection. In kidney, trans-membrane Klotho acts as essential co-receptor of fibroblast growth factor 23 (FGF23). In the heart, soluble Klotho (sKlotho) protects from systolic dysfunction independently of FGF23. Here, we analyzed the association of FGF23 and sKlotho upon progression of chronic heart failure (CHF) and analyzed Klotho expression in human hearts. Serum levels of sKlotho and FGF23 were measured in 287 patients with cardiomyopathy (CMP). Tissue samples from CMP (n = 10) and healthy control hearts (n = 10) were analyzed for Klotho mRNA and protein expression. Individuals in the first FGF23 tertile were 4.1 times more likely of freedom from death, heart transplantation or assist device implantation compared to third tertile. No relationship was found between sKlotho and the combined endpoint. Instead, Klotho mRNA encoding the full-length form was upregulated in human CMP hearts. Immunoblotting confirmed upregulation of sKlotho associated with increased expression of proteases involved in cleavage of Klotho suggesting rather local effects of Klotho in the heart. Therefore, we conclude that in contrast to FGF23, serum sKlotho is not associated with disease severit...Continue Reading

References

Aug 27, 2005·Science·Hiroshi KurosuMakoto Kuro-o
Jan 27, 2006·The Journal of Biological Chemistry·Hiroshi KurosuMakoto Kuro-o
Nov 7, 2006·Nature·Itaru UrakawaTakeyoshi Yamashita
Dec 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ci-Di ChenCarmela R Abraham
Jan 8, 2008·Biological Chemistry·Makoto Kuro-o
Oct 22, 2009·Nature Reviews. Endocrinology·M Shawkat Razzaque
Dec 1, 2010·Journal of the American Society of Nephrology : JASN·Ming Chang HuOrson W Moe
Oct 12, 2011·The Journal of Clinical Investigation·Christian FaulMyles Wolf
Dec 14, 2011·European Journal of Clinical Investigation·Max PlischkeMartin Hülsmann
Mar 21, 2012·European Journal of Heart Failure·John J V McMurrayHenry Krum
May 25, 2012·Kidney International·Myles Wolf
Aug 21, 2012·Peptides·Damien GrusonMichel F Rousseau
Nov 7, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ivana PavikAndreas L Serra
Dec 6, 2012·Nature Communications·Jian XieChou-Long Huang
Mar 12, 2013·Circulation. Heart Failure·Luigi TavazziUNKNOWN IN-HF (Italian Network on Heart Failure) Outcome Investigators
May 28, 2013·Clinical Biochemistry·Lise PedersenLars Melholt Rasmussen
Jun 12, 2013·Circulation. Heart Failure·Bonnie KyUNKNOWN CRIC Study Investigators
Oct 26, 2013·Journal of the American Society of Nephrology : JASN·Julia J SciallaUNKNOWN Chronic Renal Insufficiency Cohort (CRIC) Study Investigators
Oct 9, 2014·European Journal of Clinical Investigation·Gerhard PoelzlAndrea Griesmacher
Oct 19, 2014·Journal of the American Society of Nephrology : JASN·Ming Chang HuOrson W Moe
Dec 6, 2014·Journal of the American Society of Nephrology : JASN·Jian XieChou-Long Huang
Jul 15, 2015·American Journal of Physiology. Renal Physiology·Ellen P M van LoonJoost G J Hoenderop
Aug 13, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Manfred RichterThomas Kubin
Apr 27, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jon D WrightChou-Long Huang

❮ Previous
Next ❯

Citations

Jul 7, 2020·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Yuan HungYi-Jen Chen
Jan 23, 2021·Scientific Reports·Manabu TaneikeKeiko Yamauchi-Takihara
Oct 23, 2020·Ageing Research Reviews·Stephen F VatnerDorothy E Vatner

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
ELISA
biopsy
biopsies

Software Mentioned

SPSS
sKlotho

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

European Journal of Clinical Investigation
Gerhard PoelzlAndrea Griesmacher
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Hirotaka KomabaMasafumi Fukagawa
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Mandy WanRukshana Shroff
© 2022 Meta ULC. All rights reserved