Klotho, stem cells, and aging

Clinical Interventions in Aging
Ao BianMing-Chang Hu

Abstract

Aging is an inevitable and progressive biological process involving dysfunction and eventually destruction of every tissue and organ. This process is driven by a tightly regulated and complex interplay between genetic and acquired factors. Klotho is an antiaging gene encoding a single-pass transmembrane protein, klotho, which serves as an aging suppressor through a wide variety of mechanisms, such as antioxidation, antisenescence, antiautophagy, and modulation of many signaling pathways, including insulin-like growth factor and Wnt. Klotho deficiency activates Wnt expression and activity contributing to senescence and depletion of stem cells, which consequently triggers tissue atrophy and fibrosis. In contrast, the klotho protein was shown to suppress Wnt-signaling transduction, and inhibit cell senescence and preserve stem cells. A better understanding of the potential effects of klotho on stem cells could offer novel insights into the cellular and molecular mechanisms of klotho deficiency-related aging and disease. The klotho protein may be a promising therapeutic agent for aging and aging-related disorders.

Citations

Jan 5, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Felipe SalechAndrés Couve
Jul 16, 2019·Journal of Cachexia, Sarcopenia and Muscle·Yeshun WuLing Yang
Jun 18, 2020·Journal of Clinical Medicine·Charat ThongprayoonWisit Cheungpasitporn
May 8, 2018·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Fangfang BiWangsen Cao
May 28, 2020·Frontiers in Immunology·Rossana FranzinGiuseppe Castellano
Aug 14, 2020·Journal of Clinical Medicine·Barbara InfanteGiovanni Stallone
Nov 20, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Mujib Ullah, Zhongjie Sun
Nov 6, 2018·Neurochemical Research·Helen A RowlandKatherine A B Kellett
Jan 23, 2021·International Journal of Molecular Sciences·Marlena Typiak, Agnieszka Piwkowska
Oct 27, 2020·Stem Cells International·Provvidenza M AbruzzoCarlo Ventura

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Methods Mentioned

BETA
coimmunoprecipitation

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