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Klotho suppresses TNF-alpha-induced expression of adhesion molecules in the endothelium and attenuates NF-kappaB activation

Endocrine

Apr 16, 2009

Yoshihiro MaekawaHiromi Rakugi

Abstract

Klotho is a senescence suppressor protein that, when overexpressed, extends the lifespan of mice. Klotho-disrupted mice exhibit atherosclerosis and endothelial dysfunction, which led us to investigate the effect of the Klotho protein on vascular inflammation, particularly adhesion molec...read more

Mentioned in this Paper

Vcam1
Necrosis
Vascular Inflammations
Positive Regulation of NF-kappaB Transcription Factor Activity
Tumor Necrosis Factor-alpha
VCAM1
Tnf
Organ Culture Techniques
Western Blotting
Tnf
Paper Details
References
  • References24
  • Citations67
123
  • References24
  • Citations67
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Klotho suppresses TNF-alpha-induced expression of adhesion molecules in the endothelium and attenuates NF-kappaB activation

Endocrine

Apr 16, 2009

Yoshihiro MaekawaHiromi Rakugi

PMID: 19367378

DOI: 10.1007/s12020-009-9181-3

Abstract

Klotho is a senescence suppressor protein that, when overexpressed, extends the lifespan of mice. Klotho-disrupted mice exhibit atherosclerosis and endothelial dysfunction, which led us to investigate the effect of the Klotho protein on vascular inflammation, particularly adhesion molec...read more

Mentioned in this Paper

Vcam1
Necrosis
Vascular Inflammations
Positive Regulation of NF-kappaB Transcription Factor Activity
Tumor Necrosis Factor-alpha
VCAM1
Tnf
Organ Culture Techniques
Western Blotting
Tnf

Similar Papers Found In These Feeds

Paper Details
References
  • References24
  • Citations67
123
  • References24
  • Citations67
12345...
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