PMID: 9192868Jun 1, 1997Paper

Klumpfuss, a putative Drosophila zinc finger transcription factor, acts to differentiate between the identities of two secondary precursor cells within one neuroblast lineage

Genes & Development
X YangW Chia

Abstract

The approximately 300 distinct neurons comprising each hemineuromere of the Drosophila embryonic central nervous system are derived from a segmentally reiterated array of approximately 30 progenitor cells, neuroblasts (NBs). Each NB has a unique identity and undergoes repeated cell divisions to produce several smaller secondary precursor cells, ganglion mother cells (GMCs); each GMC divides once to produce two neurons and/or glia, thereby generating a specific lineage of neurons/glia. Understanding the generation of neuronal diversity requires not only elucidation of the molecules and mechanisms that specify NB identity but also those that act to differentiate between the cell types produced within one NB lineage. Here we show that the Drosophila Zn finger protein Klumpfuss (Klu), which shows sequence similarities to the mammalian Wilm's tumor suppressor (WT-1), acts to differentiate between the identities of the first two secondary precursor cells produced from one NB lineage. Klu is expressed in the NB4-2 lineage only after two rounds of NB cell division, in the second born GMC (GMC4-2b). In loss-of-function mutant embryos, the first born GMC (GMC4-2a) as well as its progeny neurons are duplicated; we show that this duplicati...Continue Reading

References

Feb 14, 1992·Biochemical and Biophysical Research Communications·F MatsuzakiY Nabeshima
Jun 1, 1991·Mechanisms of Development·A N BillinS J Poole
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·T DickW Chia
Jun 1, 1989·Genes & Development·N H PatelR Holmgren
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·S C FujitaS L Shotwell
Dec 1, 1993·Trends in Neurosciences·C Q Doe, G M Technau
Aug 1, 1993·Current Opinion in Genetics & Development·F Jiménez, J Modolell
Jun 18, 1993·Cell·D V VactorC S Goodman
Feb 1, 1996·Current Opinion in Neurobiology·C Q Doe, J B Skeath
Sep 1, 1984·Wilhelm Roux's Archives of Developmental Biology·Volker Hartenstein, Jose A Campos-Ortega
May 1, 1995·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Kei ItoGerhard Martin Technau

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Citations

Aug 27, 2005·PLoS Biology·Christoph Melcher, Michael J Pankratz
Aug 19, 2014·Cell and Tissue Research·Hugo GabilondoJonathan Benito-Sipos
Oct 2, 2004·Current Biology : CB·Marita BuescherWilliam Chia
Jun 3, 2004·Mechanisms of Development·Jamie C RusconiRoss Cagan
May 15, 2013·Developmental Biology·Takumi SuzukiMakoto Sato
Jan 17, 2002·Journal of Neurobiology·Dervla M Mellerick, Victoria Modica
Jan 1, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Mark ClementsJeffrey Milbrandt
Jun 29, 2001·The Journal of Experimental Zoology·J M Sullivan, D L Macmillan
Feb 11, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Rachel E Karcavich
Oct 10, 2003·Nature·Bret J Pearson, Chris Q Doe
Dec 24, 2002·Current Opinion in Nephrology and Hypertension·Ross Cagan
Jul 2, 2003·Development·Rolf Urbach, Gerhard M Technau
Nov 8, 2012·Development·Catarina C F Homem, Juergen A Knoblich
May 2, 2013·Development·María Losada-PérezJonathan Benito-Sipos

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