Knee arthrography: effects of various contrast media and epinephrine on synovial fluid

Radiology
F CorbettiS Todesco

Abstract

Changes in synovial fluid leukocytes, total protein, and total complement were studied in 58 patients after they underwent single contrast material-enhanced knee arthrography with ionic (sodium iothalamate, sodium meglumine diatrizoate, meglumine iothalamate) and nonionic (iopamidol, iohexol) contrast media. In 30 of 58 cases, 0.3 mg epinephrine was also injected. In patients examined without epinephrine, a significant increase in the number of leukocytes was observed when sodium iothalamate and sodium meglumine diatrizoate were used. When administered with epinephrine all ionic compounds produced significant leukocytosis; articular reactions were most evident in patients examined with sodium salts. No inflammatory changes in the synovial fluid were observed when nonionic compounds were used. These data suggest that sodium-containing compounds produce a greater reaction in the joint compared with other contrast media, nonionic compounds are better tolerated by the joint, and epinephrine increases the articular reaction to ionic contrast media.

Citations

Nov 28, 2012·The Veterinary Clinics of North America. Equine Practice·Alejandro Valdés-Martínez
Jul 28, 2009·Radiologic Clinics of North America·Patrick OmoumiBruno C Vande Berg
Dec 25, 2010·Journal of Magnetic Resonance Imaging : JMRI·Patrick OmoumiChristine B Chung
Sep 29, 2015·Research in Veterinary Science·Lieve De RyckeIngrid Gielen
Oct 1, 2012·Cartilage·Harri T KokkonenJuha Töyräs
Aug 1, 2021·Skeletal Radiology·Alexander OserowskyJulia Crim

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