Knee contact force in subjects with symmetrical OA grades: differences between OA severities.

Journal of Biomechanics
C Richards, Jill S Higginson

Abstract

In using musculoskeletal models, researchers can calculate muscle forces, and subsequently joint contact forces, providing insight into joint loading and the progression of such diseases as osteoarthritis (OA). The purpose of this study was to estimate the knee contact force (KCF) in patients with varying degrees of OA severity using muscle forces and joint reaction forces derived from OpenSim. Walking data was obtained from healthy individuals (n=14) and those with moderate (n=10) and severe knee OA (n=2). For each subject, we generated 3D, muscle-actuated, forward dynamic simulations of the walking trials. Muscle forces that reproduced each subject's gait were calculated. KCFs were then calculated using the vector sum of the muscle forces and joint reaction forces along the longitudinal axis of the femur. Moderate OA subjects exhibited a similar KCF pattern to healthy subjects, with lower second peaks (p=0.021). Although subjects with severe OA had similar initial peak KCF to healthy and moderate OA subjects (more than 4 times BW), the pattern of the KCF was very different between groups. After an initial peak, subjects with severe OA continually unloaded the joint, whereas healthy and moderate OA subjects reloaded the knee d...Continue Reading

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Citations

Feb 1, 2013·Journal of Biomechanical Engineering·Ross H MillerKevin J Deluzio
Feb 2, 2013·Journal of Neuroengineering and Rehabilitation·Brian A KnarrJill S Higginson
Dec 25, 2012·Biology of Sex Differences·Daniel P NicolellaWendy M Kohrt
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Feb 23, 2020·Frontiers in Physiology·Carlos Cruz-MontecinosHuub Maas
Feb 25, 2021·Medical & Biological Engineering & Computing·Yi Ting YapYu Zheng Chong

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