Knee dGEMRIC at 7 T: comparison against 1.5 T and evaluation of T1 -mapping methods

BMC Musculoskeletal Disorders
Pernilla PetersonJonas Svensson

Abstract

dGEMRIC (delayed Gadolinium Enhanced Magnetic Resonance Image of Cartilage) is a well-established technique for cartilage quality assessment in osteoarthritis at clinical field strengths. The method is robust, but requires injection of contrast agent and a cumbersome examination procedure. New non-contrast-agent-based techniques for cartilage quality assessment are currently being developed at 7 T. However, dGEMRIC remains an important reference technique during this development. The aim of this work was to compare T1 mapping for dGEMRIC at 7 T and 1.5 T, and to evaluate three T1-mapping methods at 7 T. The knee of 10 healthy volunteers and 9 patients with early signs of cartilage degradation were examined at 1.5 T and 7 T after a single (one) contrast agent injection (Gd-(DTPA)2-). Inversion recovery (IR) sequences were acquired at both field strengths, and at 7 T variable flip angle (VFA) and Look-Locker (LL) sequences were additionally acquired. T1 maps were calculated and average T1 values were estimated within superficial and deep regions-of-interest (ROIs) in the lateral and medial condyles, respectively. T1 values were 1.8 (1.4-2.3) times longer at 7 T. A strong correlation was detected between 1.5 T and 7 T T1 values (r...Continue Reading

References

Nov 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A BashirD Burstein
Jan 9, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D BursteinM L Gray
Dec 18, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C J TideriusL Dahlberg
Feb 21, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Carl Johan TideriusLeif Dahlberg
Feb 21, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sean C L DeoniTerry M Peters
Feb 3, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Carl Johan TideriusLeif Dahlberg
Apr 6, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Michael SchärPeter Boesiger
Oct 19, 2005·Investigative Radiology·Martin RohrerHanns-Joachim Weinmann
Jan 24, 2006·Investigative Radiology·Tali KimelmanPottumarthi Prasad
Jun 20, 2006·Osteoarthritis and Cartilage·C TideriusD Burstein
Aug 31, 2006·Journal of Magnetic Resonance Imaging : JMRI·Charles A McKenzieDeborah Burstein
Sep 28, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ashley WilliamsDeborah Burstein
Jan 10, 2008·Journal of Magnetic Resonance Imaging : JMRI·Wei LiPottumarthi V Prasad
Sep 26, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Tallal Charles MamischYoung-Jo Kim
Sep 30, 2009·Journal of Magnetic Resonance Imaging : JMRI·Carl SiverssonJonas Svensson
Aug 3, 2010·Journal of Magnetic Resonance Imaging : JMRI·Ernesto StaroswieckiBrian A Hargreaves
Dec 3, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Carl SiverssonYoung-Jo Kim
Jan 4, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Anup SinghRavinder Reddy
Jan 19, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kay Nehrke, Peter Börnert
Jun 13, 2012·European Radiology·Siegfried TrattnigWolfgang Bogner
Jan 14, 2017·Journal of Magnetic Resonance Imaging : JMRI·Tyler J FraumKathryn J Fowler

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Citations

Aug 23, 2019·The British Journal of Radiology·Teodoro Martín NoguerolAntonio Luna

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