Knitting the Threads of Silk through Time: Behçet's Disease-Past, Present, and Future

International Journal of Rheumatology
Fahd AdeebAlexander D Fraser

Abstract

Behçet's disease (BD) is a chronic relapsing vasculitis that affects vessels of all types and sizes with a broad spectrum of phenotypic heterogeneity and complex immunopathogenesis. Efforts by the scientific community to resolve the unmet needs of BD and gaps in our knowledge have been hampered by considerable challenges that primarily relate to the rare nature of the disease in many parts of the world and its heterogeneity. Controversies remain in many aspects of the disease including the diagnostic criteria, immunopathogenesis and biomarker discovery, geographical variation, and therapeutic considerations. In this review, we highlight recent advances in our scientific understanding of BD, shed new insights into diagnostic and treatment strategies, and discuss residual gaps in our knowledge that will serve as the basis for current and future research.

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Citations

May 18, 2019·International Journal of Rheumatic Diseases·Fares M Al ZahraniAbdullah Alsabaani
Jun 23, 2020·British Journal of Biomedical Science·O O AbdelaleemH S Elsayed
Apr 19, 2019·American Journal of Clinical Dermatology·Annika Havnaer, George Han
May 11, 2021·Indian Journal of Dermatology, Venereology and Leprology·Seetharampura Ramamurthy RadhikaT N Revathi
Jul 24, 2021·Orphanet Journal of Rare Diseases·Judith LeyensMatthias F Seidel

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Methods Mentioned

BETA
exome sequencing

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