Knock-down and speed of kill of a combination of fipronil and permethrin for the prevention of Ctenocephalides felis flea infestation in dogs

Parasites & Vectors
Lenaïg HalosF Beugnet

Abstract

A topical combination of fipronil + permethrin (Frontline Tri-Act/Frontect, Merial) has recently been developed to control fleas, ticks, mosquitoes, sandflies and stable flies on dogs. Two studies were conducted to assess its speed of kill and knock-down effect on Ctenocephalides felis fleas. The combination was compared to either fipronil alone or to a combination of permethrin, dinotefuran, and pyriproxyfen, In each study, 18 dogs were randomly allocated to one of three groups: (Group 1: untreated dog; Group 2: treated once on D0 with the combination of fipronil and permethrin; Group 3: treated once on D0 either with fipronil alone (study 1) or with a combination of permethrin, dinetofuran and pyriproxyfen (study 2)). Each dog was infested with 100 unfed adult C. felis fleas on Days 2 (study 2), 7, 14, 21 and 28. Fleas were collected from dogs at 1 h and 12 h post- infestations (PI) (study 1) or at 2 h and 6 h PI (study 2) to assess efficacy and from collection pans underneath cages 1 h (study 1) or 5 min (study 2) PI to assess knock-down effect. All treated dogs had significantly (p ≤ 0.01) lower flea counts than untreated dogs at every time point in both studies. For a whole month, a significant knock-down effect against in...Continue Reading

References

Sep 1, 1988·The Veterinary Clinics of North America. Small Animal Practice·V J Scheidt
Apr 20, 2005·Trends in Parasitology·Michael K Rust
May 1, 2009·Veterinary Parasitology·Frederic Beugnet, Jean-Lou Marié
Feb 27, 2010·Trends in Parasitology·Kristina M McElroyJennifer H McQuiston
May 26, 2012·Trends in Parasitology·Frédéric Beugnet, Michel Franc
Aug 3, 2014·Parasites & Vectors·Ferran SeguraMaría-Mercedes Nogueras
Jan 23, 2016·Parasite : Journal De La Société Française De Parasitologie·Frédéric BeugnetJosephus Fourie

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