PMID: 25730904Mar 3, 2015Paper

Knockdown of GALNT1 suppresses malignant phenotype of hepatocellular carcinoma by suppressing EGFR signaling

Oncotarget
Miao-Juei HuangMin-Chuan Huang

Abstract

O-glycosylation is a common protein modification. Aberrant O-glycosylation is associated with many cancers. GALNT1 is a GalNAc-transferase that initiates protein O-glycosylation. We found that GALNT1 is frequently up-regulated in hepatocellular carcinoma (HCC) and is associated with poor patient survival. Overexpression of GALNT1 increased and knockdown decreased HCC cell migration and invasion. Knockdown of GALNT1 inhibited EGF-induced migration and invasion. Knockdown of GALNT1 decreased EGFR activation and increased EGFR degradation, by decreasing EGFR O-glycosylation. This study demonstrates that down-regulation of GALNT1 is sufficient to suppress malignant phenotype of HCC cells by decreasing EGFR signaling. Thus, GALNT1 is a potential target in HCC.

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Citations

Nov 22, 2020·Biomolecules·Keiko Akasaka-Manya, Hiroshi Manya
Nov 20, 2020·Journal of Theoretical & Computational Chemistry·Jonathon E MohlMing-Ying Leung
Jun 22, 2021·Oncology Letters·Xiaojie SunXiangwei Meng

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