Knockdown of SNHG15 suppresses renal cell carcinoma proliferation and EMT by regulating the NF-κB signaling pathway

International Journal of Oncology
Yang DuXiuyue Yu

Abstract

Aberrant expression of long noncoding RNAs (lncRNAs) is associated with cancer tumorigenesis and progression. It has been suggested that lncRNAs may be potential clinical diagnostic and prognostic biomarkers, and therapeutic targets. In the present study, the expression levels of small nucleolar RNA host gene 15 (SNHG15) were significantly upregulated in renal cell carcinoma (RCC) tissues and cell lines compared with in adjacent tissues and a proximal tubule epithelial cell line, as determined by reverse transcription‑quantitative polymerase chain reaction. Subsequently, knockdown of SNHG15 expression with small interfering RNA inhibited RCC proliferation, invasion and migration, was determined by western blotting and Transwell assays. Furthermore, the present study suggested that SNHG15 may be involved in the nuclear factor‑κB signaling pathway, induce the epithelial‑mesenchymal transition process, and promote RCC invasion and migration.

References

Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Mar 16, 2007·Clinical Oncology : a Journal of the Royal College of Radiologists·R O EscárcegaA Zamora
Feb 7, 2008·Journal of Cellular Biochemistry·Chengyin MinGail E Sonenshein
Feb 4, 2009·Nature Reviews. Genetics·Tim R MercerJohn S Mattick
Jul 3, 2009·Genes & Development·Jeremy E WiluszDavid L Spector
Jul 12, 2011·European Urology·Börje LjungbergLambertus A Kiemeney
Nov 19, 2011·Cancer Discovery·John R Prensner, Arul M Chinnaiyan
Jun 25, 2013·Nature·UNKNOWN Cancer Genome Atlas Research Network
Sep 17, 2013·Biochemical and Biophysical Research Communications·Hidenori Tani, Masaki Torimura
Oct 10, 2013·Nature Reviews. Molecular Cell Biology·Sarah Geisler, Jeff Coller
Jan 1, 2014·European Urology·Elena S Martens-UzunovaGeorge A Calin
Nov 26, 2015·Cancer Biomarkers : Section a of Disease Markers·Meilin QinWenxin Qin
Dec 15, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Su-Xiu ChenZheng-Hua Fei
Jan 26, 2016·CA: a Cancer Journal for Clinicians·Wanqing ChenJie He
Jul 12, 2016·Molecular Oncology·Lise Lotte ChristensenClaus L Andersen
Feb 25, 2017·Biochemical and Biophysical Research Communications·Chang CaiQifeng Yang

❮ Previous
Next ❯

Citations

Nov 28, 2019·Cell Proliferation·You ShuaiJifeng Feng
Jan 10, 2019·Journal of Cellular Biochemistry·Yongcun LiuLiping Wu
Apr 23, 2020·Frontiers in Oncology·Alina-Andreea ZimtaIoana Berindan-Neagoe
Oct 22, 2020·BioMed Research International·Zhengxiang ZhangHao Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.