Knockdown of TMPRSS3 inhibits gastric cancer cell proliferation, invasion and EMT via regulation of the ERK1/2 and PI3K/Akt pathways

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Shun-Le LiZong-Zheng Ji

Abstract

The transmembrane protease, serine 3 (TMPRSS3), a member of the type II transmembrane serine protease family, plays an important role in mediating tissue development, homeostasis and various biological processes. Recently, TMPRSS3 has been reported to be involved in cancer progression. However, the role of TMPRSS3 in gastric cancer (GC) remains largely unknown. In this study, we found that TMPRSS3 was highly expressed in GC tissues and cell lines. Knockdown of TMPRSS3 inhibited GC cell proliferation, invasion and epithelial-mesenchymal transition (EMT) in vitro as well as suppressed GC cell growth and dissemination in vivo. These inhibitory effects were mediated by regulation of the ERK1/2 signaling pathway. Moreover, TMPRSS3-mediated ERK1/2 activation was dependent on the PI3K/Akt pathway. In conclusion, TMPRSS3 contributed to GC progression via activation of the PI3K/Akt/ERK signaling pathway and might act as a therapeutic target for GC treatment.

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Citations

Sep 5, 2019·Cancer Metastasis Reviews·Julia MitschkeThomas Reinheckel
May 24, 2019·International Journal of Molecular Sciences·Iris C SalaroglioChiara Riganti
Nov 18, 2018·Journal of Cellular Biochemistry·Jun-Feng Huo, Xiao-Bing Chen

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