Knockdown of zinc transporter ZIP8 expression inhibits neuroblastoma progression and metastasis in vitro

Molecular Medicine Reports
Zhengrong MeiFang He

Abstract

Neuroblastoma is one of the leading causes of cancer‑associated mortality worldwide, particularly in children, partially due to the absence of effective therapeutic targets and diagnostic biomarkers. Therefore, novel molecular targets are critical to the development of therapeutic approaches for neuroblastoma. In the present study, the functions of zinc transporter ZIP8 (Zip8), a member of the zinc transporting protein family, were investigated as novel molecular targets in neuroblastoma cancer cells. The proliferation rates of neuroblastoma cancer cells were significantly decreased when Zip8 was knocked down by lentiviral‑mediated RNA interference. Study of the molecular mechanism suggested that Zip8 modulated the expression of key genes involved in the nuclear factor‑κB signaling pathway. Furthermore, Zip8 depletion suppressed the migratory potential of neuroblastoma cancer cells by reducing the expression levels of matrix metalloproteinases. In conclusion, the results of the present study suggested that Zip8 was an important regulator of neuroblastoma cell proliferation and migration, indicating that Zip8 may be a potential anticancer therapeutic target and a promising diagnostic biomarker for human neuroblastoma.

References

Jul 10, 1998·The Proceedings of the Nutrition Society·R J Cousins
Apr 11, 2001·Mutation Research·I E Dreosti
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
May 7, 2002·Nature Reviews. Cancer·Mikala Egeblad, Zena Werb
Jan 29, 2003·Cancer Metastasis Reviews·Ananda S Prasad, Omer Kucuk
Mar 4, 2003·Nature Reviews. Cancer·Garrett M Brodeur
Jul 3, 2003·Journal of the National Cancer Institute·Michael F LeitzmannEdward L Giovannucci
Mar 24, 2004·Annals of Epidemiology·Tiejian WuEllen Smit
Jun 11, 2004·Annual Review of Nutrition·Juan P Liuzzi, Robert J Cousins
Nov 16, 2004·The Journal of Nutritional Biochemistry·Emily Ho
Jun 23, 2005·Frontiers in Bioscience : a Journal and Virtual Library·Renty B FranklinLeslie C Costello
Sep 22, 2005·Nature Reviews. Immunology·Michael Karin, Florian R Greten
Oct 4, 2005·The Journal of Clinical Investigation·Jun-Li LuoMichael Karin
May 9, 2006·Cancer Metastasis Reviews·Elena I Deryugina, James P Quigley
Apr 3, 2007·Archives of Biochemistry and Biophysics·Renty B Franklin, Leslie C Costello
Aug 4, 2007·Molecular Medicine·Kathryn M TaylorRobert I Nicholson
Sep 6, 2007·Molecular Biology Reports·Lian-ying ZhangFeng Kong
Dec 18, 2007·Expert Reviews in Molecular Medicine·Erik JohnsonPaul M Sondel
Feb 13, 2008·Cell·Matthew S Hayden, Sankar Ghosh
Apr 9, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Beth BeseckerDaren L Knoell
Dec 10, 2008·International Journal of Cancer. Journal International Du Cancer·Johannes U AmmannSimone Fulda
Apr 4, 2009·Cancer Biology & Therapy·Fariba NavidRaymond C Barfield
Apr 30, 2009·Journal of Leukocyte Biology·Tolunay B AydemirRobert J Cousins
Jun 19, 2010·The New England Journal of Medicine·John M Maris
Nov 3, 2010·Drugs of the Future·Richard K Yang, Paul M Sondel
Mar 13, 2013·Nature Reviews. Urology·Vladimir KolenkoRobert Uzzo
Mar 20, 2013·Molecular Aspects of Medicine·Jeeyon Jeong, David J Eide
May 25, 2013·Nature Reviews. Cancer·Nai-Kong V Cheung, Michael A Dyer
Nov 10, 2013·Nature Medicine·Daniela F Quail, Johanna A Joyce

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Citations

Apr 25, 2020·Frontiers in Oncology·Rikki A M BrownPeter J Leedman
Jul 3, 2019·Nutrients·Ivo F ScheiberNingning Zhao
Feb 26, 2021·Oxidative Medicine and Cellular Longevity·Lesang ShenJian Huang
May 1, 2021·International Journal of Molecular Sciences·Chiara A De BenedictisAndreas M Grabrucker

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