Knockout mice: a paradigm shift in modern immunology

Nature Reviews. Immunology
T W MakPamela S Ohashi

Abstract

In the past decade, advances in genetic engineering and mouse knockout technology have transformed our understanding of the immune system. In particular, new perspectives on T-cell development, co-stimulation and activation have emerged from the study of single and multiple gene-knockout animals, as well as from conditional knockout and 'knock-in' mutants. Analysis of these animals has clarified important intracellular signalling pathways and has shed light on the regulatory mechanisms that govern normal immune responses and autoimmunity.

References

Mar 6, 1992·Cell·P MombaertsV E Papaioannou
May 14, 1992·Nature·T J MolinaA Veillette
Jan 1, 1992·Annual Review of Immunology·B H Koller, O Smithies
Sep 8, 1995·Science·R KühnK Rajewsky
May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·A MaC B Thompson
Aug 1, 1994·Immunity·J XuR A Flavell
Nov 12, 1993·Science·T M KündigI Horak
Jan 14, 1994·Cell·K A HogquistF R Carbone
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J ChenF W Alt
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·C A Mallick-WoodA C Hayday
Apr 1, 1997·Current Opinion in Immunology·H J Fehling, H von Boehmer

❮ Previous
Next ❯

Citations

Nov 30, 2005·Transgenic Research·Caroline LassnigMathias Müller
Sep 2, 2003·Cytokine & Growth Factor Reviews·Binghe WangDaniel N Sauder
Feb 21, 2002·Trends in Parasitology·Mark C RigbyLori Stevens
Sep 20, 2005·Nature Biotechnology·Shang-Zhong XuDavid J Beech
Jun 21, 2006·Nature Immunology·Caiyi C LiStephen T Smale
Mar 22, 2002·Nature Reviews. Immunology·Doreen A Cantrell
Oct 9, 2002·Cellular Microbiology·George S Yap, Alan Sher
Mar 3, 2012·Science·Jarrod A DudakovMarcel R M van den Brink
Apr 15, 2006·Clinical Microbiology Reviews·D M ScollardD L Williams
Feb 16, 2005·Annual Review of Physiology·Warren Burggren, Stephen Warburton
Nov 3, 2012·Clinical & Developmental Immunology·Sean R StowellJeanne E Hendrickson
May 12, 2011·PloS One·Taichang YuanHaihua Gu
Feb 14, 2012·Current Opinion in Biotechnology·Wolfgang W A Schamel, Michael Reth
Feb 1, 2011·Developmental and Comparative Immunology·Jacques Robert, Nicholas Cohen
Mar 18, 2009·Immunological Reviews·Jing Jin GuAnn Marie Pendergast
May 15, 2007·Immunological Reviews·Martin MetzStephen J Galli
Sep 7, 2007·Oral Microbiology and Immunology·J AlayanC S Farah
Mar 20, 2010·Anaesthesia·J J Pandit, J M Handy
Apr 15, 2005·Molecular Immunology·Danielle A R MagalhãesGeraldo A S Passos
May 8, 2004·Seminars in Immunology·Edward M BertramTania H Watts
Sep 18, 2012·Critical Reviews in Microbiology·Derrick LouzRob C Hoeben
Jun 2, 2015·Immunology and Cell Biology·Mahmood Y BilalJon Cd Houtman
Jul 23, 2004·Current Biology : CB·Ronald L Wange
May 4, 2004·Nature Reviews. Immunology·Margot Thome
Oct 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thanh V NguyenGen-Sheng Feng
Jan 4, 2003·Nature Reviews. Immunology·Paul H Plotz
Apr 2, 2004·Nature Reviews. Immunology·Robert T Abraham, Arthur Weiss
Feb 14, 2017·European Surgery : ACA : Acta Chirurgica Austriaca·Chen WenweiXia Peng
Dec 30, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Connie L SommersPaul E Love
Apr 2, 2004·Nature Reviews. Immunology·Michael Reth, Tilman Brummer
May 1, 2021·Frontiers in Cellular and Infection Microbiology·Jonathon KeckBernard P Arulanandam
Dec 18, 2008·Bioconjugate Chemistry·Stephen Mather
Oct 6, 2021·Cell Reports·Sinéad KinsellaJarrod A Dudakov

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Emergency Medicine Journal : EMJ
Bernard A Foëx
Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
Uri Galili
© 2022 Meta ULC. All rights reserved