PMID: 9427251Jan 14, 1998Paper

Knockout of the vesicular monoamine transporter 2 gene results in neonatal death and supersensitivity to cocaine and amphetamine

Neuron
Y M WangM G Caron

Abstract

Vesicular monoamine transporters are known to transport monoamines from the cytoplasm into secretory vesicles. We have used homologous recombination to generate mutant mice lacking the vesicular monoamine transporter 2 (VMAT2), the predominant form expressed in the brain. Newborn homozygotes die within a few days after birth, manifesting severely impaired monoamine storage and vesicular release. In heterozygous adult mice, extracellular striatal dopamine levels, as well as K+- and amphetamine-evoked dopamine release, are diminished. The observed changes in presynaptic homeostasis are accompanied by a pronounced supersensitivity of the mice to the locomotor effects of the dopamine agonist apomorphine, the psychostimulants cocaine and amphetamine, and ethanol. Importantly, VMAT2 heterozygous mice do not develop further sensitization to repeated cocaine administration. These observations stress the importance of VMAT2 in the maintenance of presynaptic function and suggest that these mice may provide an animal model for delineating the mechanisms of vesicular release, monoamine function, and postsynaptic sensitization associated with drug abuse.

References

Aug 11, 1992·Journal of Neuroscience Methods·A D SmithJ B Justice
May 1, 1992·Trends in Pharmacological Sciences·H H Samson, R A Harris
Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J D EricksonB J Hoffman
May 1, 1992·Trends in Pharmacological Sciences·W L Woolverton, K M Johnson
Jan 1, 1990·Annals of the New York Academy of Sciences·M E Wolf, R H Roth
Aug 1, 1988·Journal of Clinical Psychopharmacology·P Seeman
Jan 1, 1987·Schizophrenia Bulletin·H Y Meltzer
Mar 1, 1971·Journal of Neurochemistry·J B MaconJ Glowinski
Jan 1, 1995·Annual Review of Neuroscience·D W Self, E J Nestler
Apr 13, 1995·Nature·S A ThomasR D Palmiter
Sep 1, 1994·Brain & Development·H S Singer
Mar 1, 1994·Brain Research. Molecular Brain Research·A M GonzalezG R Uhl
Dec 1, 1993·Journal of Neurochemistry·J D Erickson, L E Eiden
Sep 1, 1993·Brain Research. Brain Research Reviews·T E Robinson, K C Berridge
Jul 1, 1993·Journal of Neuroscience Methods·K T KawagoeR M Wightman
Nov 1, 1995·Neuropharmacology·A Merickel, R H Edwards
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·J D EricksonE Weihe
Jan 1, 1997·Annual Review of Neuroscience·Y Liu, R H Edwards
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·N HiroiE J Nestler
Oct 6, 1997·Science·E J Nestler, G K Aghajanian
Dec 5, 1997·Brain Research. Molecular Brain Research·N Takahashi, G Uhl
Nov 18, 1955·Science·B B BRODIEP A SHORE

❮ Previous
Next ❯

Citations

Aug 2, 2003·Annals of Neurology·Linan Chen, Xiaoxi Zhuang
Apr 24, 2001·Muscle & Nerve·E A Fon, R H Edwards
Aug 1, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Paul E HarrisAntonella Maffei
Mar 19, 2013·Journal of Neural Transmission·Christoph FehrUlrich W Preuss
May 22, 2013·Current Neurology and Neuroscience Reports·Shawn P AlterGary W Miller
Mar 29, 2001·Current Psychiatry Reports·M A Enoch, D Goldman
Mar 5, 2009·Molecular Neurobiology·Thomas S Guillot, Gary W Miller
Nov 19, 2003·European Journal of Pharmacology·Marten P SmidtJ Peter H Burbach
Jul 19, 2005·Neurobiology of Disease·Carol X-Q ChenYong-Jian Liu
Apr 15, 2004·Neurochemistry International·E Sylvester ViziTibor Zelles
Jun 16, 2005·Progress in Neurobiology·David SulzerAurelio Galli
Aug 6, 1999·Biological Psychiatry·R R GainetdinovM G Caron
Jan 3, 2001·European Journal of Pharmacology·J Veenstra-VanderWeeleE H Cook
Nov 27, 2002·European Journal of Pharmacology·Ryan R MetzgerAnnette E Fleckenstein
Nov 14, 2002·Neurotoxicology·Maria E ReveronGary W Miller
Feb 13, 2001·Journal of Neuroscience Methods·T L ColliverA G Ewing
Apr 7, 2000·Journal of Neuroscience Methods·M J LogmanR M Wightman
Jun 15, 1999·Trends in Pharmacological Sciences·D L MurphyA Heils
Sep 28, 1999·Trends in Pharmacological Sciences·G W MillerM G Caron
Mar 8, 2002·Trends in Neurosciences·M VilaS Przedborski
Oct 16, 1999·Brain Research. Molecular Brain Research·K ItokawaG R Uhl
Aug 15, 2002·Neurochemistry International·Marco A M PradoFernando G de Mello
Aug 26, 1998·Drug and Alcohol Dependence·S G Amara, M S Sonders
Aug 19, 2005·Journal of Medicinal Chemistry·Guangrong ZhengPeter A Crooks
Aug 5, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nicolas Narboux-NêmeRaymond Mongeau
Mar 24, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·James J CrowleyIrwin Lucki
Dec 7, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Niels H JensenBryan L Roth
Apr 20, 2000·Journal of Clinical Pharmacy and Therapeutics·C BetzR B Raffa
Jan 26, 2000·Journal of Neurochemistry·R A BundeyD A Kendall
Feb 1, 2013·The New England Journal of Medicine·Jennifer J RilstoneBerge A Minassian
Jul 9, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Irene BrunkGudrun Ahnert-Hilger
Dec 27, 2011·Cold Spring Harbor Perspectives in Biology·Randy D Blakely, Robert H Edwards
Sep 1, 2000·Alcoholism, Clinical and Experimental Research·C M Singh, U Heberlein
Jul 29, 2009·Molecular and Cellular Biology·Braulio M de CastroVania F Prado

❮ Previous
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