Knowing one's place: a free-energy approach to pattern regulation

Journal of the Royal Society, Interface
Karl J FristonGiovanni Pezzulo

Abstract

Understanding how organisms establish their form during embryogenesis and regeneration represents a major knowledge gap in biological pattern formation. It has been recently suggested that morphogenesis could be understood in terms of cellular information processing and the ability of cell groups to model shape. Here, we offer a proof of principle that self-assembly is an emergent property of cells that share a common (genetic and epigenetic) model of organismal form. This behaviour is formulated in terms of variational free-energy minimization-of the sort that has been used to explain action and perception in neuroscience. In brief, casting the minimization of thermodynamic free energy in terms of variational free energy allows one to interpret (the dynamics of) a system as inferring the causes of its inputs-and acting to resolve uncertainty about those causes. This novel perspective on the coordination of migration and differentiation of cells suggests an interpretation of genetic codes as parametrizing a generative model-predicting the signals sensed by cells in the target morphology-and epigenetic processes as the subsequent inversion of that model. This theoretical formulation may complement bottom-up strategies-that curre...Continue Reading

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Citations

Apr 12, 2016·Communicative & Integrative Biology·Douglas J BlackistonMichael Levin
Feb 14, 2016·British Medical Bulletin·James E ClarkJulia L Newton
Nov 17, 2015·Integrative Biology : Quantitative Biosciences From Nano to Macro·G Pezzulo, M Levin
Mar 26, 2016·Seminars in Cell & Developmental Biology·Lawrence EdelsteinJohn Smythies
Jul 23, 2016·Frontiers in Psychology·František Baluška, Michael Levin
Aug 11, 2016·Frontiers in Psychology·Maxwell J D RamsteadLaurence J Kirmayer
Oct 6, 2016·Brain Sciences·Alianna J Maren
Nov 4, 2016·Journal of the Royal Society, Interface·Giovanni Pezzulo, Michael Levin
Nov 9, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Gary McDowellMichael Levin
Mar 10, 2016·PLoS Biology·Biswa SenguptaKarl J Friston
Jan 19, 2018·Journal of the Royal Society, Interface·Michael KirchhoffJulian Kiverstein
Apr 23, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Santosh Manicka, Michael Levin
Jun 24, 2017·Journal of the Royal Society, Interface·Paco Calvo, Karl Friston
Aug 20, 2019·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Iris Hunger
Jan 30, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Michael Levin
Dec 24, 2019·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Thomas ParrKarl Friston
Oct 16, 2019·Neural Computation·Takuya IsomuraKarl Friston
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Aug 16, 2019·Communicative & Integrative Biology·Chris Fields, Michael Levin
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Jul 4, 2020·The Behavioral and Brain Sciences·Chris Fields, James F Glazebrook
Jun 12, 2018·Synthese·Shaun Gallagher, Micah Allen
Dec 24, 2018·Neural Computation·Sebastian Gottwald, Daniel A Braun
Sep 27, 2019·Frontiers in Psychology·Filippo Cieri, Roberto Esposito
May 12, 2020·Frontiers in Computational Neuroscience·Daphne DemekasKarl J Friston
Apr 10, 2020·Frontiers in Psychology·Jared VasilMaxwell J D Ramstead
Jun 17, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Chris Fields, Michael Levin
Apr 13, 2018·Journal of the Royal Society, Interface·Axel ConstantKarl J Friston
Nov 26, 2020·Journal of the Royal Society, Interface·Sergio RubinKarl Friston
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Feb 26, 2021·Synthese·Maxwell J D RamsteadKarl J Friston
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Methods Mentioned

BETA
protein folding

Software Mentioned

spm
_ ADEM
Matlab

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