Knowing what's growing: Why ductal and intraductal prostate cancer matter.

Science Translational Medicine
Mitchell G LawrenceGail P Risbridger

Abstract

Prostate cancer is a common malignancy, but only some tumors are lethal. Accurately identifying these tumors will improve clinical practice and instruct research. Aggressive cancers often have distinctive pathologies, including intraductal carcinoma of the prostate (IDC-P) and ductal adenocarcinoma. Here, we review the importance of these pathologies because they are often overlooked, especially in genomics and preclinical testing. Pathology, genomics, and patient-derived models show that IDC-P and ductal adenocarcinoma accompany multiple markers of poor prognosis. Consequently, "knowing what is growing" will help translate preclinical research to pinpoint and treat high-risk prostate cancer in the clinic.

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Citations

Oct 24, 2020·Journal of the Endocrine Society·Gail P RisbridgerRenea A Taylor
Mar 9, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ken ChowNiall M Corcoran
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May 13, 2021·IJU Case Reports·Kazunori ShojoMototsugu Oya
May 18, 2021·Asian Journal of Urology·Hiten Rh Patel, Reena Patel
Jun 12, 2021·SLAS Discovery·Nicholas ChooKaylene J Simpson
May 16, 2021·Advances in Anatomic Pathology·Murali Varma
Jul 18, 2021·Current Oncology Reports·Bryden ConsidineMichael E Hurwitz

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