PMID: 9526083May 2, 1998Paper

Knowing where things are parahippocampal involvement in encoding object locations in virtual large-scale space

Journal of Cognitive Neuroscience
E A MaguireJ O'Keefe

Abstract

The involvement of the medial temporal-lobe region in allocentric mapping of the environment has been observed in human lesion and functional imaging work. Cognitive models of environmental learning ascribe a key role to salient landmarks in representing large-scale space. In the present experiments we examined the neural substrates of the topographical memory acquisition process when environmental landmarks were more specifically identifiable. Using positron emission tomography (PET), we measured regional cerebral blood flow changes while normal subjects explored and learned in a virtual reality environment. One experiment involved an environment containing salient objects and textures that could be used to discriminate different rooms. Another experiment involved a plain empty environment in which rooms were distinguishable only by their shape. Learning in both cases activated a network of bilateral occipital, medial parietal, and occipitotemporal regions. The presence of salient objects and textures in an environment additionally resulted in increased activity in the right parahippocampal gyrus. This region was not activated during exploration of the empty environment. These findings suggest that encoding of salient objects ...Continue Reading

References

Nov 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K J WorsleyP Neelin
Feb 1, 1992·Brain : a Journal of Neurology·J SergentB MacDonald
Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J V HaxbyS I Rapoport
Jul 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K J FristonR S Frackowiak
Jan 1, 1989·Neuropsychologia·L H GoldsteinC E Polkey
Mar 1, 1987·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·M Habib, A Sirigu
Dec 1, 1987·Journal of Experimental Child Psychology·C C Presson
Feb 1, 1986·Archives of Neurology·T LandisE P Palmer
Jan 1, 1981·Neuropsychologia·M L Smith, B Milner
Aug 29, 1995·Proceedings of the National Academy of Sciences of the United States of America·R MalachR B Tootell
Apr 25, 1995·Proceedings of the National Academy of Sciences of the United States of America·C MoscovitchS Houle
Apr 1, 1995·Brain : a Journal of Neurology·P C FletcherR J Dolan
Mar 1, 1995·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·N KapurR S Frackowiak
Oct 1, 1994·Brain : a Journal of Neurology·B M de JongS Zeki
Oct 1, 1993·Neuropsychologia·S J AngeliM Mishkin
Feb 1, 1993·Brain : a Journal of Neurology·P M GrasbyR J Dolan
Jan 1, 1993·Experimental Brain Research·E T RollsY Miyashita
Nov 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J L DeenL A Ross
Feb 15, 1996·Nature·A MartinJ V Haxby
Mar 1, 1996·Neuropsychologia·J D FeigenbaumR G Morris
Nov 1, 1996·Cerebral Cortex·G K AguirreM D'Esposito
Nov 22, 1996·Proceedings. Biological Sciences·C J PriceK J Friston
Dec 22, 1996·Proceedings. Biological Sciences·E A MaguireC D Frith
Sep 1, 1995·NeuroImage·P C FletcherR J Dolan
Oct 1, 1995·Journal of Cognitive Neuroscience·E MelletB Mazoyer

❮ Previous
Next ❯

Citations

Apr 20, 2010·Psychopharmacology·Andra M SmithIan Cameron
Feb 27, 2010·Experimental Brain Research·Gaspare GalatiGiorgia Committeri
Nov 6, 2012·Experimental Brain Research·Aiden E G F ArnoldGiuseppe Iaria
Feb 23, 2010·Psychological Research·Luca Latini-CorazziniPatrick Péruch
Jun 3, 2004·Neuroscience and Biobehavioral Reviews·Zsuzsa Káldy, Natasha Sigala
Jan 20, 2004·Neuropsychologia·M-J CaronS Chouinard
Mar 20, 2001·Neuropsychologia·C L WorsleyR G Morris
Jun 26, 2001·Brain Research. Brain Research Reviews·R P KesselsA Postma
Jun 23, 2000·Behavioural Brain Research·N ForemanB Leplow
Nov 14, 2001·Neurobiology of Aging·S D MoffatS M Resnick
May 14, 1999·Current Opinion in Neurobiology·E A MaguireJ O'Keefe
Aug 5, 2004·Neuropsychology·David M ParslowRobin G Morris
Aug 5, 2004·Neuropsychology·Janet D Feigenbaum, Robin G Morris
May 27, 2004·Nature Neuroscience·Hugo J Spiers, Eleanor A Maguire
May 18, 2004·Nature Neuroscience·Gabriele Janzen, Miranda van Turennout
Jul 21, 2004·Nature Reviews. Neuroscience·Moshe Bar
Mar 19, 2011·Nature Reviews. Neuroscience·Dwight J KravitzMortimer Mishkin
Apr 22, 2006·The Quarterly Journal of Experimental Psychology : QJEP·Gabriele Janzen
Aug 30, 2008·Experimental Aging Research·Paul E GilbertClaire Murphy
Feb 5, 2000·Memory·A R Mayes, D Montaldi
Sep 16, 2008·Brain : a Journal of Neurology·Yifat Glikmann-JohnstonDavid C Reutens
Oct 14, 1998·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J O'KeefeE A Maguire
Dec 17, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·E A Maguire, L Cipolotti
Dec 18, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·P TurrizianiC Caltagirone
Jun 26, 2004·Annual Review of Neuroscience·Larry R SquireRobert E Clark
Apr 19, 2000·Journal of Cognitive Neuroscience·R Cabeza, L Nyberg
May 29, 2004·Journal of Cognitive Neuroscience·Vinod GoelJordan Grafman
Mar 6, 2007·Journal of Cognitive Neuroscience·Patrick KhaderFrank Rösler
Feb 21, 2008·Journal of Cognitive Neuroscience·Peggy St JacquesRoberto Cabeza
Jun 16, 2011·Journal of Cognitive Neuroscience·Joost Wegman, Gabriele Janzen
Nov 10, 2011·Journal of Cognitive Neuroscience·Ariel Tankus, Itzhak Fried
Jun 14, 2005·The Journal of Clinical Investigation·Andreas Meyer-LindenbergKaren Faith Berman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.