Knowledge, Attitudes, and Experiences of HIV Pre-Exposure Prophylaxis (PrEP) Trial Participants in Botswana

World Journal of AIDS
Lauren ToledoPoloko M Kebaabetswe

Abstract

Recent clinical trials have shown that a daily dose of oral TDF/FTC pre-exposure prophylaxis (PrEP) is effective in reducing human immunodeficiency (HIV) risk. Understanding trial participants' perspectives about retention and PrEP adherence is critical to inform future PrEP trials and the scale-up and implementation of PrEP programs. We analyzed 53 in-depth interviews conducted in April 2010 with participants in the TDF2 study, a Phase 3, randomized, double-blind, placebo-controlled clinical trial of daily oral TDF/FTC with heterosexual men and women in Francistown and Gaborone, Botswana. We examined participants' knowledge, attitudes, and experiences of the trial, identified facilitators and barriers to enrollment and retention, and compared participant responses by study site, sex, and study drug adherence. Our findings point to several factors to consider for participant retention and adherence in PrEP trials and programs, including conducting pre-enrollment education and myth reduction counseling, providing accurate estimates of participant obligations and side effect symptoms, ensuring participant understanding of the effects of non-adherence, gauging personal commitment and interest in study outcomes, and developing a st...Continue Reading

Associated Clinical Trials

References

Jan 19, 2006·Advances in Therapy·Kem P KruegerBill Felkey
Oct 8, 2008·Current HIV/AIDS Reports·Michael J Stirratt, Christopher M Gordon
Nov 26, 2010·The New England Journal of Medicine·Robert M GrantUNKNOWN iPrEx Study Team
Feb 1, 2011·Contemporary Clinical Trials·Quarraisha Abdool KarimSalim S Abdool Karim
Mar 9, 2011·Contemporary Clinical Trials·Paul J FeldblumKofi Opoku
Jan 24, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Norma C WareDavid R Bangsberg
Jul 13, 2012·The New England Journal of Medicine·Jared M BaetenUNKNOWN Partners PrEP Study Team
Jul 13, 2012·The New England Journal of Medicine·Michael C ThigpenUNKNOWN TDF2 Study Group
Jul 13, 2012·The New England Journal of Medicine·Lut Van DammeUNKNOWN FEM-PrEP Study Group
Mar 16, 2013·Current HIV/AIDS Reports·Jared M Baeten, Robert Grant
Dec 11, 2013·World Journal of AIDS·Rebecca GiguereAlex Carballo-Diéguez

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Citations

Oct 19, 2016·The Journal of the Association of Nurses in AIDS Care : JANAC·Monique S Balthazar
Apr 27, 2016·AIDS and Behavior·Helena A KwakwaTimothy P Flanigan
Mar 5, 2020·Culture, Health & Sexuality·Fiona ScorgieUNKNOWN EMPOWER study team

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